产品
编 号：F535428
分子式：C42H72O14
分子量：801.01
分子式：C42H72O14
分子量：801.01
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 94987-10-7
产品详情
生物活性：
Gypenoside LI, a gypenoside monomer, possesses anti-tumor activity. Gypenoside LI induces cell apoptosis, cell cycle and migration.
体外研究：
Gypenoside LI (0-80 μM) inhibits A549 cells in a dose-dependent manner. Gypenoside LI induces G2/M and arrest apoptosis in A549 cells.Gypenoside LI increases intracellular ROS level. Gypenoside LI suppressed migration of A549 cells.Gypenoside LI could obviously suppress the expression of CDK1 protein rather thanCDK2 and CDK4 proteins.Gypenoside LI inhibits cell proliferation and upregulates expression of miR-128-3p in melanoma cells.Gypenoside LI (75 and 29.71 μg/mL) can induce intrinsic apoptosis along with S phase arrest. Gypenoside LI inhibited the colony formation ability of melanoma through inhibition of the Wnt/β-catenin signaling pathway.Gypenoside LI induces PARP cleavage, increased the expression of cleaved caspase-9 and BID death agonist, and downregulates the expression of FLIP (long form) and BCl-2 in the A375 and SK-MEL-28 melanoma cells.
Gypenoside LI, a gypenoside monomer, possesses anti-tumor activity. Gypenoside LI induces cell apoptosis, cell cycle and migration.
体外研究：
Gypenoside LI (0-80 μM) inhibits A549 cells in a dose-dependent manner. Gypenoside LI induces G2/M and arrest apoptosis in A549 cells.Gypenoside LI increases intracellular ROS level. Gypenoside LI suppressed migration of A549 cells.Gypenoside LI could obviously suppress the expression of CDK1 protein rather thanCDK2 and CDK4 proteins.Gypenoside LI inhibits cell proliferation and upregulates expression of miR-128-3p in melanoma cells.Gypenoside LI (75 and 29.71 μg/mL) can induce intrinsic apoptosis along with S phase arrest. Gypenoside LI inhibited the colony formation ability of melanoma through inhibition of the Wnt/β-catenin signaling pathway.Gypenoside LI induces PARP cleavage, increased the expression of cleaved caspase-9 and BID death agonist, and downregulates the expression of FLIP (long form) and BCl-2 in the A375 and SK-MEL-28 melanoma cells.
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