产品
编 号：F534775
分子式：C29H26N2O4
分子量：466.53
分子式：C29H26N2O4
分子量：466.53
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 947669-86-5
产品详情
生物活性：
WWL113 is a selective and orally active Ces3 and Ces1f inhibitor, with IC50 values of 120 nM and 100 nM for Ces3 and Ces1f, respectively. WWL113 appears to show excellent selectivity for the 60-kDa serine hydrolase (or hydrolases).
体内研究：
WWL113 (30 mg/kg, orally once a day) results in major improvement of multiple features of metabolic syndrome and ameliorated obesity-diabetes in mice with lowered levels of nonesterified free fatty acids (NEFAs), triglycerides (TGs), total cholesterol and fasted glucose as well as enhanced glucose tolerance.WWL113 ameliorates obesity-diabetes in mice.Animal Model:Eight-week-old db/db mice (n = 10 per group).
Dosage:30 mg/kg.
Administration:Orally once a day for 3 weeks.
Result:Corrected multiple features of metabolic syndrome in db/db mice.
体外研究：
Ces3 and Ces1f are endoplasmic reticulum glycoproteins that have been previously associated with adipocyte lipolysis. WWL113 inhibits mouse recombinant Ces1, Ces1c, and ABHD6 at 10 μM.WWL113 (1 μM) significantly increases UCP1 protein expression in brown adipocytes.WWL113 has a partial, statistically significant inhibitory effect on blocking the buildup of PGE2.
WWL113 is a selective and orally active Ces3 and Ces1f inhibitor, with IC50 values of 120 nM and 100 nM for Ces3 and Ces1f, respectively. WWL113 appears to show excellent selectivity for the 60-kDa serine hydrolase (or hydrolases).
体内研究：
WWL113 (30 mg/kg, orally once a day) results in major improvement of multiple features of metabolic syndrome and ameliorated obesity-diabetes in mice with lowered levels of nonesterified free fatty acids (NEFAs), triglycerides (TGs), total cholesterol and fasted glucose as well as enhanced glucose tolerance.WWL113 ameliorates obesity-diabetes in mice.Animal Model:Eight-week-old db/db mice (n = 10 per group).
Dosage:30 mg/kg.
Administration:Orally once a day for 3 weeks.
Result:Corrected multiple features of metabolic syndrome in db/db mice.
体外研究：
Ces3 and Ces1f are endoplasmic reticulum glycoproteins that have been previously associated with adipocyte lipolysis. WWL113 inhibits mouse recombinant Ces1, Ces1c, and ABHD6 at 10 μM.WWL113 (1 μM) significantly increases UCP1 protein expression in brown adipocytes.WWL113 has a partial, statistically significant inhibitory effect on blocking the buildup of PGE2.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备