产品
编 号：F534605
分子式：C21H31N3O3
分子量：373.49
分子式：C21H31N3O3
分子量：373.49
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CAS No: 947257-66-1
产品详情
生物活性：
D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity.
体内研究：
D-3263 (50 or 100 mg/kg/d) alone or with Finasteride (10 mg/kg/d) results in reduction in prostate hyperplasia of rats with evidence of a dose response. The highest dose of the TRPM8 agonist D-3263, given in combination with Finasteride, results in lower prostate weights than the highest dose of D-3263 or Finasteride given alone, suggesting a potential additive effect.
体外研究：
D-3263 induces calcium flux and cell death in in vitro cells expressing TRPM8.
D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity.
体内研究：
D-3263 (50 or 100 mg/kg/d) alone or with Finasteride (10 mg/kg/d) results in reduction in prostate hyperplasia of rats with evidence of a dose response. The highest dose of the TRPM8 agonist D-3263, given in combination with Finasteride, results in lower prostate weights than the highest dose of D-3263 or Finasteride given alone, suggesting a potential additive effect.
体外研究：
D-3263 induces calcium flux and cell death in in vitro cells expressing TRPM8.
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