产品
编 号：F533928
分子式：C14H22Cl2N2O2S
分子量：353.31
分子式：C14H22Cl2N2O2S
分子量：353.31
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 946387-07-1
产品详情
生物活性：
RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50s for all three species (hTRPV4: 2.3 μM, mTRPV4: 5.9 μM, rTRPV4: 3.2 μM). RN-1734 clearly decreases the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells.
体内研究：
RN-1734 (0.5 μL；显微注射泵；每日一次，持续 5 周) 显著逆转 CPZ 诱导的脱髓鞘小鼠的 CNP 蛋白减少并改善髓鞘形成。Animal Model:CPZ-induced demyelination mouse model (C57BL/6 male mice)
Dosage: 0.5 μl (10 μM in 5% DMSO and 0.9% NaCl)
Administration:Microinjector pump for 5 weeks
Result:Significantly reversed the decrease in CNP protein and improved myelination in CPZ-induced demyelination mouse.
体外研究：
RN-1734 (27 小时；10 μM) 可逆转 CM (LPS 激活的小胶质细胞组) 细胞凋亡诱导的少突胶质细胞凋亡率增加。 RN-1734 (27 小时；10 μM) 减轻 CM 诱导的 CNP 降低。
RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50s for all three species (hTRPV4: 2.3 μM, mTRPV4: 5.9 μM, rTRPV4: 3.2 μM). RN-1734 clearly decreases the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells.
体内研究：
RN-1734 (0.5 μL；显微注射泵；每日一次，持续 5 周) 显著逆转 CPZ 诱导的脱髓鞘小鼠的 CNP 蛋白减少并改善髓鞘形成。Animal Model:CPZ-induced demyelination mouse model (C57BL/6 male mice)
Dosage: 0.5 μl (10 μM in 5% DMSO and 0.9% NaCl)
Administration:Microinjector pump for 5 weeks
Result:Significantly reversed the decrease in CNP protein and improved myelination in CPZ-induced demyelination mouse.
体外研究：
RN-1734 (27 小时；10 μM) 可逆转 CM (LPS 激活的小胶质细胞组) 细胞凋亡诱导的少突胶质细胞凋亡率增加。 RN-1734 (27 小时；10 μM) 减轻 CM 诱导的 CNP 降低。
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