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编 号：F533709
分子式：C19H25N3O2
分子量：327.42
分子式：C19H25N3O2
分子量：327.42
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CAS No: 945828-50-2
产品详情
生物活性：
AA29504 is a ethyl carbamate with γ-aminobutyric acid (GABAA(HY-L120) receptor activity. AA29504 inhibits the delivery of the neurotransmitter gamma-aminobutyric acid in the central nervous system. AA29504 can be used to research anxiety, insomnia and other neuropsychiatric diseases .
体内研究：
AA29504 (0.5, 2 或 4 mg/kg, 皮下注射) 在雄性 SD (Spraguee Dawley) 大鼠中有抗焦虑作用。 AA29504 (4 mg/kg, 皮下注射)在乙醇的协同作用下显著减弱了雄性 SD 大鼠的运动协调性。AA29504 (10 mg/kg, 皮下注射)在雄性维斯塔大鼠中对杏仁核点燃的癫痫发作有治疗作用。Animal Model:Male Spraguee Dawley rats
Dosage:0.5, 2 or 4 mg/kg
Administration:Subcutaneous injections
Result:Reduced the number of vocalizations at 4 mg/kg and reversed partially the freezing behavior at 2 mg/kg.
Animal Model:Male Spraguee Dawley rats
Dosage:4 mg/kg
Administration:Subcutaneous injections
Result:Reduced the time the rats stayed on the rotarod at 4 mg/kg.
Animal Model:Male Wistar rats
Dosage:10 mg/kg
Administration:Subcutaneous injections
Result:Reduced from 4.9 to 2.0 in amygdala kindled seizures response.
体外研究：
AA29504 (0.1, 1, 10, 100 μM, 72 h) 在非洲爪蟾卵母细胞中可开启 Kv7 电压门控钾离子 (KCNQ) 通道。AA29504 (1 μM) 对在非洲爪蟾卵母细胞中表达的GABAA受体有正向调节作用, EC501.4 μM。AA29504 (1 μM, 10 s) 在前额叶皮层锥体神经元中对加波沙朵 (gaboxadol) 诱导的电流有显著增强作用。
AA29504 is a ethyl carbamate with γ-aminobutyric acid (GABAA(HY-L120) receptor activity. AA29504 inhibits the delivery of the neurotransmitter gamma-aminobutyric acid in the central nervous system. AA29504 can be used to research anxiety, insomnia and other neuropsychiatric diseases .
体内研究：
AA29504 (0.5, 2 或 4 mg/kg, 皮下注射) 在雄性 SD (Spraguee Dawley) 大鼠中有抗焦虑作用。 AA29504 (4 mg/kg, 皮下注射)在乙醇的协同作用下显著减弱了雄性 SD 大鼠的运动协调性。AA29504 (10 mg/kg, 皮下注射)在雄性维斯塔大鼠中对杏仁核点燃的癫痫发作有治疗作用。Animal Model:Male Spraguee Dawley rats
Dosage:0.5, 2 or 4 mg/kg
Administration:Subcutaneous injections
Result:Reduced the number of vocalizations at 4 mg/kg and reversed partially the freezing behavior at 2 mg/kg.
Animal Model:Male Spraguee Dawley rats
Dosage:4 mg/kg
Administration:Subcutaneous injections
Result:Reduced the time the rats stayed on the rotarod at 4 mg/kg.
Animal Model:Male Wistar rats
Dosage:10 mg/kg
Administration:Subcutaneous injections
Result:Reduced from 4.9 to 2.0 in amygdala kindled seizures response.
体外研究：
AA29504 (0.1, 1, 10, 100 μM, 72 h) 在非洲爪蟾卵母细胞中可开启 Kv7 电压门控钾离子 (KCNQ) 通道。AA29504 (1 μM) 对在非洲爪蟾卵母细胞中表达的GABAA受体有正向调节作用, EC501.4 μM。AA29504 (1 μM, 10 s) 在前额叶皮层锥体神经元中对加波沙朵 (gaboxadol) 诱导的电流有显著增强作用。
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