产品
编 号：F533431
分子式：C21H17N5O3
分子量：387.39
分子式：C21H17N5O3
分子量：387.39
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CAS No: 945008-17-3
产品详情
生物活性：
TM6008 is a potent and orally active prolyl hydroxylase (PHD) inhibitor. TM6008 chelats transition metal (copper) and inhibits the autoxidation of ascorbic acid with an IC50 value is 0.57 μM. TM6008 ?exerts organ protection against ischemia?in vivo and can be used for cerebrovascular disease research.
体内研究：
TM6008 (p.o.; 50 mg/kg; single dosage) exhibits plasma Tmax, Cmax, and T1/2 values of 3.5 hour, 0.9 μg/mL and 1.5 hour for TM6008 in rat.TM6008 (p.o.; 100 mg/kg; 7 days) protects against hypoxia-induced apoptotic neuronal death and decreases the number of apoptotic cells in Gerbils after a 5-minute transient global cerebral ischemia.Animal Model:Gerbils after a 5-minute transient global cerebral ischemia
Dosage:100 mg/kg
Administration:p.o.; 100 mg/kg; 7 days
Result:Exerted organ protection against ischemia?in vivo.
TM6008 is a potent and orally active prolyl hydroxylase (PHD) inhibitor. TM6008 chelats transition metal (copper) and inhibits the autoxidation of ascorbic acid with an IC50 value is 0.57 μM. TM6008 ?exerts organ protection against ischemia?in vivo and can be used for cerebrovascular disease research.
体内研究：
TM6008 (p.o.; 50 mg/kg; single dosage) exhibits plasma Tmax, Cmax, and T1/2 values of 3.5 hour, 0.9 μg/mL and 1.5 hour for TM6008 in rat.TM6008 (p.o.; 100 mg/kg; 7 days) protects against hypoxia-induced apoptotic neuronal death and decreases the number of apoptotic cells in Gerbils after a 5-minute transient global cerebral ischemia.Animal Model:Gerbils after a 5-minute transient global cerebral ischemia
Dosage:100 mg/kg
Administration:p.o.; 100 mg/kg; 7 days
Result:Exerted organ protection against ischemia?in vivo.
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