产品
编 号:F532449
分子式:C16H14O5
分子量:286.28
产品类型
结构图
CAS No: 94344-54-4
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产品详情
生物活性:
Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells.
体外研究:
Sappanchalcone has a statistically significant effect on HCT116 cells than on SW480 cells (IC50= 37.33 μM and 54.23 μM, respectively). Sappanchalcone reduces MMP with a significant increase in ROS levels in human colon cancer cells. Sappanchalcone triggered phosphorylation of p53, which is involved in the activation of caspases and increased expression of Bax in HCT116 cells.