产品
编 号：F529878
分子式：C8H15NOS2
分子量：205.34
分子式：C8H15NOS2
分子量：205.34
产品类型
规格
价格
是否有货
100mg
240
In-stock
500mg
680
In-stock
结构图
CAS No: 940-69-2
产品详情
生物活性：
Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway.
体外研究：
Lipoamide (10-100 μM; 24 h) 可减轻 H2O2 或 6-OHDA 诱导的 PC12 细胞损伤和凋亡，降低 LDH 渗漏和 Caspase-3 的活性。Lipoamide (100 μM; 8 h) 还上调 PC12 细胞中 Nrf2 的表达，促进 Nrf2 的核易位和下游基因表达，如诱导 Nrf2 调控的抗氧化基因的转录。
Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway.
体外研究：
Lipoamide (10-100 μM; 24 h) 可减轻 H2O2 或 6-OHDA 诱导的 PC12 细胞损伤和凋亡，降低 LDH 渗漏和 Caspase-3 的活性。Lipoamide (100 μM; 8 h) 还上调 PC12 细胞中 Nrf2 的表达，促进 Nrf2 的核易位和下游基因表达，如诱导 Nrf2 调控的抗氧化基因的转录。
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