产品
编 号：F529862
分子式：C23H33NO7S2
分子量：499.64
分子式：C23H33NO7S2
分子量：499.64
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
400
In-stock
100mg
680
In-stock
500mg
2384
In-stock
结构图
CAS No: 94055-76-2
产品详情
生物活性：
Suplatast Tosilate (IPD 1151T) is an orally active Th2 cytokine inhibitor which can inhibit both IL-4 and IL-5 production from Th2 cells and suppress IgE synthesis. Suplatast Tosilate is an anti-allergic agent. Suplatast Tosilate has antiasthmatic, anti-inflammatory and antifibrotic activity.
体内研究：
Suplatast Tosilate (100 mg/kg; once daily for 21 d) inhibits the production of Th2 cytokines, which inhibits eosinophil infiltration into the murine airway, IgE synthesis, and development of BHR, in a murine model of asthma.Suplatast Tosilate (100 μg/kg; once daily for 14 d) strongly suppresses immunoglobulin E contents in serum.Animal Model:Female BALB/c mice (6-8 weeks old) are immunized with ovalbumin
Dosage:100 mg/kg
Administration:P.o. once a day for 21 days
Result:Reduced the number of total cells and eosinophils.Almost completely inhibited the development of antigen-induced bronchial hyperresponsiveness (BHR).Decreased the levels of IL-4, IL-5 and IL-13.
体外研究：
IPD-1151T (1-10 μM; 10 d) induces a concentration-dependent suppression of purified allergen (Cry j 1)-dependent IgE synthesis in autologous B cell cultures mediated by SN-4, without significantly affecting the IgG synthesis.IPD-1151T (1-10 μM; 24 h) clearly depresses phytohemagglutinin (PHA)-induced expression of IL-4 mRNA in normal peripheral blood mononuclear cells (PBMC).
Suplatast Tosilate (IPD 1151T) is an orally active Th2 cytokine inhibitor which can inhibit both IL-4 and IL-5 production from Th2 cells and suppress IgE synthesis. Suplatast Tosilate is an anti-allergic agent. Suplatast Tosilate has antiasthmatic, anti-inflammatory and antifibrotic activity.
体内研究：
Suplatast Tosilate (100 mg/kg; once daily for 21 d) inhibits the production of Th2 cytokines, which inhibits eosinophil infiltration into the murine airway, IgE synthesis, and development of BHR, in a murine model of asthma.Suplatast Tosilate (100 μg/kg; once daily for 14 d) strongly suppresses immunoglobulin E contents in serum.Animal Model:Female BALB/c mice (6-8 weeks old) are immunized with ovalbumin
Dosage:100 mg/kg
Administration:P.o. once a day for 21 days
Result:Reduced the number of total cells and eosinophils.Almost completely inhibited the development of antigen-induced bronchial hyperresponsiveness (BHR).Decreased the levels of IL-4, IL-5 and IL-13.
体外研究：
IPD-1151T (1-10 μM; 10 d) induces a concentration-dependent suppression of purified allergen (Cry j 1)-dependent IgE synthesis in autologous B cell cultures mediated by SN-4, without significantly affecting the IgG synthesis.IPD-1151T (1-10 μM; 24 h) clearly depresses phytohemagglutinin (PHA)-induced expression of IL-4 mRNA in normal peripheral blood mononuclear cells (PBMC).
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