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编 号：F529193
分子式：C27H21Cl2N3O7
分子量：570.38
分子式：C27H21Cl2N3O7
分子量：570.38
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CAS No: 93908-02-2
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生物活性：
Rebeccamycin, an antitumor antibiotic, inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I and has negligible effect on protein kinase C and topoisomerase II.
体内研究：
Rebeccamycin (2-256 mg/kg; i.p.; daily for 9 days) prolongs survival in B16 melanoma, L1210 leukemia.Animal Model:CDF1 mice (B16 melanoma, L1210 leukemia)
Dosage:2, 4, 8, 16, 32, 64, 128, 256 mg/kg
Administration:I.p.; daily for 9 days
Result:Prolongation of survival of the mice at dose levels ranging from 8 to 256 mg/kg.
体外研究：
Rebeccamycin is an antitumor antibiotic produced by the actinomycete Saccharotrix aerocolonigenes with activity against several human tumor cell lines, including A549 (lung adenocarcinoma), HCT-116 (colon carcinoma), and KB (nasopharyngeal carcinoma) .Rebeccamycin shows antibacterial activity against several Gram-positive bacteria, including Staphylococcus aureus and Streptococcus faecalis.
Rebeccamycin, an antitumor antibiotic, inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I and has negligible effect on protein kinase C and topoisomerase II.
体内研究：
Rebeccamycin (2-256 mg/kg; i.p.; daily for 9 days) prolongs survival in B16 melanoma, L1210 leukemia.Animal Model:CDF1 mice (B16 melanoma, L1210 leukemia)
Dosage:2, 4, 8, 16, 32, 64, 128, 256 mg/kg
Administration:I.p.; daily for 9 days
Result:Prolongation of survival of the mice at dose levels ranging from 8 to 256 mg/kg.
体外研究：
Rebeccamycin is an antitumor antibiotic produced by the actinomycete Saccharotrix aerocolonigenes with activity against several human tumor cell lines, including A549 (lung adenocarcinoma), HCT-116 (colon carcinoma), and KB (nasopharyngeal carcinoma) .Rebeccamycin shows antibacterial activity against several Gram-positive bacteria, including Staphylococcus aureus and Streptococcus faecalis.
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