产品
编 号：F527604
分子式：C20H19N3O6S
分子量：429.45
分子式：C20H19N3O6S
分子量：429.45
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 936095-50-0
产品详情
生物活性：
UBP316 (ACET) is a highly potent and selective kainate receptor GluK1 (GluR5) antagonist, with a Kb value of 1.4 nM. UBP316 is effective at blocking the depression of both field excitatory postsynaptic potentials (fEPSPs) and monosynaptically-evoked GABAergic transmission induced by ATPA, a GluK1 selective agonist.
体外研究：
UBP316 is ineffective at GluK2 (GluR6) receptors at all concentrations tested (up to 100 μM) and had no effect at GluK3 (GluR7) when tested at 1 μM.UBP316 (200 nM) reduces short-term facilitation of pre-synaptic calcium transients following repetitive spikes.UBP316 effectively antagonises GluK1-mediated depression of excitatory transmission in CA1 region of the hippocampus in vitro.UBP316 blocks induction of NMDA receptor-independent long-term potentiation (LTP).
UBP316 (ACET) is a highly potent and selective kainate receptor GluK1 (GluR5) antagonist, with a Kb value of 1.4 nM. UBP316 is effective at blocking the depression of both field excitatory postsynaptic potentials (fEPSPs) and monosynaptically-evoked GABAergic transmission induced by ATPA, a GluK1 selective agonist.
体外研究：
UBP316 is ineffective at GluK2 (GluR6) receptors at all concentrations tested (up to 100 μM) and had no effect at GluK3 (GluR7) when tested at 1 μM.UBP316 (200 nM) reduces short-term facilitation of pre-synaptic calcium transients following repetitive spikes.UBP316 effectively antagonises GluK1-mediated depression of excitatory transmission in CA1 region of the hippocampus in vitro.UBP316 blocks induction of NMDA receptor-independent long-term potentiation (LTP).
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