产品
编 号：F526911
分子式：C19H16ClN5O2
分子量：381.82
分子式：C19H16ClN5O2
分子量：381.82
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 934282-55-0
产品详情
生物活性：
AZD 2066 is a selective, orally active and brain-penetrant antagonist of mGluR5. AZD 2066 has antinociception effects.
体内研究：
AZD 2066 (0.3-30 mg/kg; p.o.) shows discriminative effects in rats.Animal Model:Male Wistar rats (weighing 240-250 g)
Dosage:0.03, 0.1, 0.3, 1, 3, 10, 30 mg/kg
Administration:P.o. (60 minutes after administration)
Result:Caused full and dose-dependent AZD9272-appropriate responding.
体外研究：
AZD 2066 (1-10 μM) inhibits Ca2+ response, with IC50s of 27.2±9.1, 3.56±0.52, 96.2±17.8, and 380±78.0 nM in mGlu5/HEK cells and striatal, hippocampal, and cortical cultures respectively.AZD 2066 (1-10 μM) inhibits the oscillatory Ca2+ response which induced by bath application of DHPG, and blocks either DHPG or Quis e?ects in mGlu5/HEK cells.AZD 2066 (1-10 μM) has less e?ective in striatal neurons.
AZD 2066 is a selective, orally active and brain-penetrant antagonist of mGluR5. AZD 2066 has antinociception effects.
体内研究：
AZD 2066 (0.3-30 mg/kg; p.o.) shows discriminative effects in rats.Animal Model:Male Wistar rats (weighing 240-250 g)
Dosage:0.03, 0.1, 0.3, 1, 3, 10, 30 mg/kg
Administration:P.o. (60 minutes after administration)
Result:Caused full and dose-dependent AZD9272-appropriate responding.
体外研究：
AZD 2066 (1-10 μM) inhibits Ca2+ response, with IC50s of 27.2±9.1, 3.56±0.52, 96.2±17.8, and 380±78.0 nM in mGlu5/HEK cells and striatal, hippocampal, and cortical cultures respectively.AZD 2066 (1-10 μM) inhibits the oscillatory Ca2+ response which induced by bath application of DHPG, and blocks either DHPG or Quis e?ects in mGlu5/HEK cells.AZD 2066 (1-10 μM) has less e?ective in striatal neurons.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备