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编 号:F525627
分子式:C26H22N4O3
分子量:438.48
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10mM*1mL in DMSO
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5mg
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10mg
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50mg
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100mg
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生物活性:
PPQ-102 (CFTR Inhibitor) is a reversible CFTR inhibitor that completely inhibits CFTR chloride currents (IC50 ~90 nM). PPQ-102 is not affected by membrane potential-dependent cell allocation or blocking efficiency (uncharged at physiological pH) and effectively prevents cyst enlargement in polycystic kidney disease.

体外研究:
PPQ-102 (0,0.5,5 μM,4 天) 在 PKD 胚胎肾器官培养模型中预防和逆转肾囊肿扩张。 PPQ-102 (0,0.5,5 μM,3 天) 显示出减少预制囊肿中液体积聚的能力。
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