产品
编 号：F525589
分子式：C11H14O2
分子量：178.23
分子式：C11H14O2
分子量：178.23
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
100
In-stock
结构图
CAS No: 93-15-2
产品详情
生物活性：
Methyl Eugenol is a bait that has oral activity against oriental fruit fly (Hendel).Methyl Eugenol has anti-cancer and anti-inflammatory activities. Methyl Eugenol can induce Autophagy in cells. Methyl Eugenol can be used in the study of intestinal ischemia/reperfusion injury.
体内研究：
Methyl Eugenol (100 mg/kg; 口腔插管; 一天一次连续 30 天) 在肠缺血/再灌注损伤 (I/R) 的 Wistar 大鼠中具有抗炎作用，且可以缓解肠缺血/再灌注损伤。Animal Model:Adult Wistar rats (Rattus norvegicus) model of intestinal ischemia/reperfusion injury
Dosage:100 mg/kg
Administration:Oral intubation; Once daily for 30 days. Before underwent laparotomy with SMA occlusion 30 min of ischemia followed by 60 min of reperfusion.
Result:Significantly decreased the elevated LDH, MDA, and NO levels and concurrently increased the antioxidant biomarkers under test in the intestinal tissue.Significantly downregulate the mRNA expression levels of TNF-α and IL-6.
体外研究：
Methyl Eugenol (25% (2 mL)-100% (8 mL)) 能够以剂量依赖方式诱捕桔色小蠊。Methyl Eugenol (3.12-200 μM; 48 h) 在人视网膜母细胞瘤 RB355 细胞中，可以通过诱导 (50 μM; 24 h) 细胞自噬和抑制 (50 μM; 48 h) 细胞的 PI3K/mTOR/Akt 信号通路的方式来抑制细胞增殖 (IC50=50 μM)。 Methyl Eugenol (25-100 μM) 可以将 RB355 细胞的细胞周期阻滞在 G2/M 期。
Methyl Eugenol is a bait that has oral activity against oriental fruit fly (Hendel).Methyl Eugenol has anti-cancer and anti-inflammatory activities. Methyl Eugenol can induce Autophagy in cells. Methyl Eugenol can be used in the study of intestinal ischemia/reperfusion injury.
体内研究：
Methyl Eugenol (100 mg/kg; 口腔插管; 一天一次连续 30 天) 在肠缺血/再灌注损伤 (I/R) 的 Wistar 大鼠中具有抗炎作用，且可以缓解肠缺血/再灌注损伤。Animal Model:Adult Wistar rats (Rattus norvegicus) model of intestinal ischemia/reperfusion injury
Dosage:100 mg/kg
Administration:Oral intubation; Once daily for 30 days. Before underwent laparotomy with SMA occlusion 30 min of ischemia followed by 60 min of reperfusion.
Result:Significantly decreased the elevated LDH, MDA, and NO levels and concurrently increased the antioxidant biomarkers under test in the intestinal tissue.Significantly downregulate the mRNA expression levels of TNF-α and IL-6.
体外研究：
Methyl Eugenol (25% (2 mL)-100% (8 mL)) 能够以剂量依赖方式诱捕桔色小蠊。Methyl Eugenol (3.12-200 μM; 48 h) 在人视网膜母细胞瘤 RB355 细胞中，可以通过诱导 (50 μM; 24 h) 细胞自噬和抑制 (50 μM; 48 h) 细胞的 PI3K/mTOR/Akt 信号通路的方式来抑制细胞增殖 (IC50=50 μM)。 Methyl Eugenol (25-100 μM) 可以将 RB355 细胞的细胞周期阻滞在 G2/M 期。
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