产品
编 号：F524557
分子式：C22H26N4O3
分子量：394.47
分子式：C22H26N4O3
分子量：394.47
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 928774-43-0
产品详情
生物活性：
PF 03716556 is a potent, selective, competitive and reversible acid pump (H+,K+-ATPase) antagonist with pIC50s of 6.026, 6.038 and 6.009 for porcine, canine, and human recombinant gastric H+,K+-ATPase, respectively. PF 03716556 is inactive against other receptors, ion channels, and enzymes. PF 03716556 has the potential for gastroesophageal reflux disease research.
体内研究：
PF 03716556 (1-10 mg/kg；十二指肠内给药；一次；雄性 Sprague-Dawley 大鼠) 治疗以剂量依赖性方式抑制大鼠胃酸分泌。Animal Model:Male Sprague-Dawley rats (250 -300 g) treated with Pentagastrin
Dosage:1 mg/kg, 3 mg/kg, 10 mg/kg
Administration:Intraduodenal administration; once
Result:Inhibited gastric acid secretion in a dose-dependent manner.
体外研究：
在猪离子紧密膜囊泡中，PF 03716556 以浓度依赖性方式抑制 H+、K+-ATPase 活性，在 pH 7.4 时 pIC50 为 7.095。
PF 03716556 is a potent, selective, competitive and reversible acid pump (H+,K+-ATPase) antagonist with pIC50s of 6.026, 6.038 and 6.009 for porcine, canine, and human recombinant gastric H+,K+-ATPase, respectively. PF 03716556 is inactive against other receptors, ion channels, and enzymes. PF 03716556 has the potential for gastroesophageal reflux disease research.
体内研究：
PF 03716556 (1-10 mg/kg；十二指肠内给药；一次；雄性 Sprague-Dawley 大鼠) 治疗以剂量依赖性方式抑制大鼠胃酸分泌。Animal Model:Male Sprague-Dawley rats (250 -300 g) treated with Pentagastrin
Dosage:1 mg/kg, 3 mg/kg, 10 mg/kg
Administration:Intraduodenal administration; once
Result:Inhibited gastric acid secretion in a dose-dependent manner.
体外研究：
在猪离子紧密膜囊泡中，PF 03716556 以浓度依赖性方式抑制 H+、K+-ATPase 活性，在 pH 7.4 时 pIC50 为 7.095。
产品资料
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