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编 号：F522183
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1mg
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CAS No: 923950-08-7
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生物活性：
Dulaglutide (LY2189265) is a glucagon-like peptide-1 (GLP-1) receptor agonist. Dulaglutide can be uesd for the research of type 2 diabetes (T2D) .
体内研究：
Dulaglutide (0, 0.05, 0.5, 1.5, or 5 mg/kg; s.c.; twice week, for 93 weeks) increases the incidence of thyroid C-cell hyperplasia and neoplasia in the rat carcinogenicity study.Animal Model:Rats and Transgenic mice
Dosage:0, 0.05, 0.5, 1.5, or 5 mg/kg; 0, 0.3, 1, or 3 mg/kg
Administration:SC, twice week, for 93 weeks; SC, twice week, for 26 weeks
Result:Statistically increaseddiffuse C-cell hyperplasia and adenomas at ＞0.5 mg/kg.Decreased Systemic exposures over time in mice.
体外研究：
Dulaglutide (50 nM and 100 nM; 24 h) ameliorates ox-LDL-induced oxidative stress and suppresses ox-LDL-induced mitochondrial dysfunction in human aortic endothelial cells (HAECs).
Dulaglutide (LY2189265) is a glucagon-like peptide-1 (GLP-1) receptor agonist. Dulaglutide can be uesd for the research of type 2 diabetes (T2D) .
体内研究：
Dulaglutide (0, 0.05, 0.5, 1.5, or 5 mg/kg; s.c.; twice week, for 93 weeks) increases the incidence of thyroid C-cell hyperplasia and neoplasia in the rat carcinogenicity study.Animal Model:Rats and Transgenic mice
Dosage:0, 0.05, 0.5, 1.5, or 5 mg/kg; 0, 0.3, 1, or 3 mg/kg
Administration:SC, twice week, for 93 weeks; SC, twice week, for 26 weeks
Result:Statistically increaseddiffuse C-cell hyperplasia and adenomas at ＞0.5 mg/kg.Decreased Systemic exposures over time in mice.
体外研究：
Dulaglutide (50 nM and 100 nM; 24 h) ameliorates ox-LDL-induced oxidative stress and suppresses ox-LDL-induced mitochondrial dysfunction in human aortic endothelial cells (HAECs).
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