产品
编 号：F521299
分子式：C13H8ClN5OS
分子量：317.75
分子式：C13H8ClN5OS
分子量：317.75
产品类型
规格
价格
是否有货
结构图
CAS No: 922050-57-5
产品详情
生物活性：
HS56 is an ATP-competitive dual Pim/DAPK3 inhibitor with Ki values of 0.26, 0.208, 2.94, and ＞100 μM for DAPK3, Pim-3, Pim-1, and Pim-2, respectively. HS56 inhibits LC20 phosphorylation and smooth muscle contraction. HS56 decreases blood pressure in spontaneously hypertensive mice. HS56 can be used in research of hypertension.
体内研究：
HS56 (10 and 20 mg/kg; i.v.; 单次注射) 降低自发性高血压小鼠的血压 (BP)。Animal Model:Spontaneously hypertensive renin transgene and wild-type (WT) mice
Dosage:10 and 20 mg/kg
Administration:Intravenous injection, single injection
Result:Induced dose-dependent decreases in systolic blood pressure.
体外研究：
HS56 (50 μM; 16 h) 延迟离体大鼠尾动脉 VSM 组织中的力开始，降低收缩力，并降低 LC20 磷酸化。
HS56 is an ATP-competitive dual Pim/DAPK3 inhibitor with Ki values of 0.26, 0.208, 2.94, and ＞100 μM for DAPK3, Pim-3, Pim-1, and Pim-2, respectively. HS56 inhibits LC20 phosphorylation and smooth muscle contraction. HS56 decreases blood pressure in spontaneously hypertensive mice. HS56 can be used in research of hypertension.
体内研究：
HS56 (10 and 20 mg/kg; i.v.; 单次注射) 降低自发性高血压小鼠的血压 (BP)。Animal Model:Spontaneously hypertensive renin transgene and wild-type (WT) mice
Dosage:10 and 20 mg/kg
Administration:Intravenous injection, single injection
Result:Induced dose-dependent decreases in systolic blood pressure.
体外研究：
HS56 (50 μM; 16 h) 延迟离体大鼠尾动脉 VSM 组织中的力开始，降低收缩力，并降低 LC20 磷酸化。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备