产品
编 号：F520491
分子式：C15H14N6O3
分子量：326.31
分子式：C15H14N6O3
分子量：326.31
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 91917-65-6
产品详情
生物活性：
Ro15-4513, imidazobenzodiazepinone derivative, is a partial inverse agonist of benzodiazepine receptor (BZR). Ro15-4513 is a potent ethanol antagonist. Ro15-4513 has anti-anxiety effect. Ro15-4513 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
体内研究：
Ro 15-4513 (i.p.; 3?mg/kg; 10?min before being tested) completely inhibits the ethanol-induced (1.8?g/kg) reduction in total locomotor activity and partly the reduction in rearing. Ro 15-4513 (i.p.; 3?mg/kg; 15?min before administration of 1.5?g/kg ethanol) reverses ethanol-induced sedation in GABAA receptor δ subunit-deficient mice. Animal Model:Male C57BL/6J mice
Dosage:3?mg/kg
Administration:I.p.; 10?min before being tested
Result:Completely inhibited the ethanol-induced reduction in total locomotor activity and partly the reduction in rearing.
体外研究：
Ro15-4513 usually acts as a partial inverse agonist at GABAA receptors, except an agonist for α4 and α6 subunit-containing ones.
Ro15-4513, imidazobenzodiazepinone derivative, is a partial inverse agonist of benzodiazepine receptor (BZR). Ro15-4513 is a potent ethanol antagonist. Ro15-4513 has anti-anxiety effect. Ro15-4513 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
体内研究：
Ro 15-4513 (i.p.; 3?mg/kg; 10?min before being tested) completely inhibits the ethanol-induced (1.8?g/kg) reduction in total locomotor activity and partly the reduction in rearing. Ro 15-4513 (i.p.; 3?mg/kg; 15?min before administration of 1.5?g/kg ethanol) reverses ethanol-induced sedation in GABAA receptor δ subunit-deficient mice. Animal Model:Male C57BL/6J mice
Dosage:3?mg/kg
Administration:I.p.; 10?min before being tested
Result:Completely inhibited the ethanol-induced reduction in total locomotor activity and partly the reduction in rearing.
体外研究：
Ro15-4513 usually acts as a partial inverse agonist at GABAA receptors, except an agonist for α4 and α6 subunit-containing ones.
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