产品
编 号：F520276
分子式：C26H31Cl2N5O4
分子量：548.46
分子式：C26H31Cl2N5O4
分子量：548.46
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
结构图
CAS No: 918639-08-4
产品详情
生物活性：
Bosutinib (hydrate) is an oral Src/Abl tyrosine kinase inhibito with IC50 of 1.2 nM and 1 nM, respectively.
体内研究：
Bosutinib (hydrate) (oral gavage; 75 mg/kg twice daily or 150 mg/kg once daily) has activity against human KU812 xenografts in nude mice. Bosutinib (hydrate) (150 mg/kg; once daily, 5 days weekly) has activity against syngeneic Bcr-Abl WT and mutant Ba/F3 xenografts.Animal Model:KU812CM L xenograft model
Dosage:75 mg/kg twice daily or 150 mg/kg once daily
Administration:Bosutinib (oral gavage; 75 mg/kg twice daily or 150 mg/kg once daily)
Result:Had the therapeutic activity and produced a dose- and schedule-dependent weight loss.
Animal Model:Syngeneic Bcr-Abl WT and mutant Ba/F3 xenografts
Dosage:150 mg/kg
Administration:Bosutinib (150 mg/kg; once daily, 5 days weekly)
Result:Decreased the rate of tumor growth and prolonged event-free survival of mice.
体外研究：
Bosutinib (hydrate) is an active inhibitor of Bcr-Abl in several chronic myelogenous leukemia cell lines, with IC50 values in the low nanomolar range.
Bosutinib (hydrate) is an oral Src/Abl tyrosine kinase inhibito with IC50 of 1.2 nM and 1 nM, respectively.
体内研究：
Bosutinib (hydrate) (oral gavage; 75 mg/kg twice daily or 150 mg/kg once daily) has activity against human KU812 xenografts in nude mice. Bosutinib (hydrate) (150 mg/kg; once daily, 5 days weekly) has activity against syngeneic Bcr-Abl WT and mutant Ba/F3 xenografts.Animal Model:KU812CM L xenograft model
Dosage:75 mg/kg twice daily or 150 mg/kg once daily
Administration:Bosutinib (oral gavage; 75 mg/kg twice daily or 150 mg/kg once daily)
Result:Had the therapeutic activity and produced a dose- and schedule-dependent weight loss.
Animal Model:Syngeneic Bcr-Abl WT and mutant Ba/F3 xenografts
Dosage:150 mg/kg
Administration:Bosutinib (150 mg/kg; once daily, 5 days weekly)
Result:Decreased the rate of tumor growth and prolonged event-free survival of mice.
体外研究：
Bosutinib (hydrate) is an active inhibitor of Bcr-Abl in several chronic myelogenous leukemia cell lines, with IC50 values in the low nanomolar range.
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