产品
编 号：F520050
分子式：C14H19N3S
分子量：261.39
分子式：C14H19N3S
分子量：261.39
产品类型
规格
价格
是否有货
结构图
CAS No: 91-80-5
产品详情
生物活性：
Methapyrilene is a histamine antagonist, a pyridine chemical with anticholinergic activity. Methapyrilene can cause target organ-specific epigenetic alterations, such as a decrease in DNA methylation levels. Methapyrilene induces hepatocellular carcinoma in rats.
体内研究：
Methapyrilene (gavage with water (vehicle), 50 or 150 mg/kg, daily, 3 days) can induce hepatotoxicity and lead to periportal hepatic necrosis in rats.Animal Model:Male Wistar derived AlpK:APfSD (Alderley Park) rats
Dosage:50 mg/kg, 150 mg/kg
Administration:Gavage with water (vehicle), daily, 3 days
Result:Showed mild to moderate periportal hepatocyte degeneration and necrosis as well as acute inflammatory cells were observed in the filtering periportal vein at a dose concentration of 150 mg/kg.Decreased levels of both glucose and glycogen in the liver.Showed higher levels of succinic acid and dimethylglycine of urine obtained from the low dose group of 50 mg/kg.
体外研究：
Methapyrilene (650 μM, 72 h) decreases the transcriptional level of transferrin and is accompanied by a decrease in transferrin protein levels in HepRG cells.
Methapyrilene is a histamine antagonist, a pyridine chemical with anticholinergic activity. Methapyrilene can cause target organ-specific epigenetic alterations, such as a decrease in DNA methylation levels. Methapyrilene induces hepatocellular carcinoma in rats.
体内研究：
Methapyrilene (gavage with water (vehicle), 50 or 150 mg/kg, daily, 3 days) can induce hepatotoxicity and lead to periportal hepatic necrosis in rats.Animal Model:Male Wistar derived AlpK:APfSD (Alderley Park) rats
Dosage:50 mg/kg, 150 mg/kg
Administration:Gavage with water (vehicle), daily, 3 days
Result:Showed mild to moderate periportal hepatocyte degeneration and necrosis as well as acute inflammatory cells were observed in the filtering periportal vein at a dose concentration of 150 mg/kg.Decreased levels of both glucose and glycogen in the liver.Showed higher levels of succinic acid and dimethylglycine of urine obtained from the low dose group of 50 mg/kg.
体外研究：
Methapyrilene (650 μM, 72 h) decreases the transcriptional level of transferrin and is accompanied by a decrease in transferrin protein levels in HepRG cells.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备