产品
编 号：F519786
分子式：C12H15N5O2S
分子量：293.34
分子式：C12H15N5O2S
分子量：293.34
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 91742-10-8
产品详情
生物活性：
HA-1004 is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 is an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models.
体内研究：
HA-1004 (40 nmol/day；由微型泵注入，流速=1 μL/h) 与吗啡同时作用，在大鼠中拮抗吗啡戒断时 ERK1/2 和 TH 的磷酸化，抑制 NA 转换的增加。
HA-1004 is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 is an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models.
体内研究：
HA-1004 (40 nmol/day；由微型泵注入，流速=1 μL/h) 与吗啡同时作用，在大鼠中拮抗吗啡戒断时 ERK1/2 和 TH 的磷酸化，抑制 NA 转换的增加。
产品资料
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