产品
编 号：F519146
分子式：C28H32ClN3O6
分子量：542.02
分子式：C28H32ClN3O6
分子量：542.02
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
400
In-stock
结构图
CAS No: 91599-74-5
产品详情
生物活性：
Benidipine hydrochloride is an orally active calcium channel antagonist. Benidipine hydrochloride can inhibit cell proliferation and apoptosis. Benidipine hydrochloride has antioxidant activity and can increase nitric oxide synthase activity and improve coronary circulation in hypertensive rats.
体内研究：
Benidipine hydrochloride (3-10 μg/kg, 静脉注射) 在家兔中显示出明显的抗细胞凋亡作用，且与血流动力学无关。Benidipine hydrochloride (5 mg/kg, 每天静脉注射持续6周) 增加高血压大鼠内皮细胞型一氧化氮合酶 (eNOS) 活性，改善冠状动脉循环。Benidipine hydrochloride (1-10 mg/kg, 口服, 每日1次，持续1周) 对大鼠缺血再灌注损伤有显著的心脏保护作用。Animal Model:MI/R rabbits model
Dosage: 3-10 μg/kg
Administration:i.v.
Result:Caused a significant decrease in HR ( heart rate), MABP (mean arterial blood pressure), and PRI (pressure-rate index) at 10 μg/kg.Decreased apoptotic positive cells to 7.4% at 3 μg/kg.
Animal Model:Renovascular hypertensive rats (RHR) model
Dosage:5 mg/kg
Administration:i.v.
Result:Decreased the blood pressure and coronary vascular resistance index.Increased nitrite production and eNOS mRNA expression and the coronary flow at rest, the capillary density.
Animal Model:Rat heart model
Dosage:1-10 mg/kg
Administration:p.o.
Result:Increased the post-ischemic recovery of LVDP and LV dP/dt max (LVDP: 87.5±10.1 vs 64.6±11.9%;LV dP/dt max: 97.8±10.4 vs 70.2±15.7%) at 3 mg/kg.
体外研究：
Benidipine hydrochloride (0.01-1 μM, 7 天) 通过增强磷酸化 Akt 促进小鼠内皮细胞分化。Benidipine hydrochloride (0.1-10 μM, 48 h) 在 G0/G1 和 G1/S 期均能明显抑制系膜细胞的增殖。
Benidipine hydrochloride is an orally active calcium channel antagonist. Benidipine hydrochloride can inhibit cell proliferation and apoptosis. Benidipine hydrochloride has antioxidant activity and can increase nitric oxide synthase activity and improve coronary circulation in hypertensive rats.
体内研究：
Benidipine hydrochloride (3-10 μg/kg, 静脉注射) 在家兔中显示出明显的抗细胞凋亡作用，且与血流动力学无关。Benidipine hydrochloride (5 mg/kg, 每天静脉注射持续6周) 增加高血压大鼠内皮细胞型一氧化氮合酶 (eNOS) 活性，改善冠状动脉循环。Benidipine hydrochloride (1-10 mg/kg, 口服, 每日1次，持续1周) 对大鼠缺血再灌注损伤有显著的心脏保护作用。Animal Model:MI/R rabbits model
Dosage: 3-10 μg/kg
Administration:i.v.
Result:Caused a significant decrease in HR ( heart rate), MABP (mean arterial blood pressure), and PRI (pressure-rate index) at 10 μg/kg.Decreased apoptotic positive cells to 7.4% at 3 μg/kg.
Animal Model:Renovascular hypertensive rats (RHR) model
Dosage:5 mg/kg
Administration:i.v.
Result:Decreased the blood pressure and coronary vascular resistance index.Increased nitrite production and eNOS mRNA expression and the coronary flow at rest, the capillary density.
Animal Model:Rat heart model
Dosage:1-10 mg/kg
Administration:p.o.
Result:Increased the post-ischemic recovery of LVDP and LV dP/dt max (LVDP: 87.5±10.1 vs 64.6±11.9%;LV dP/dt max: 97.8±10.4 vs 70.2±15.7%) at 3 mg/kg.
体外研究：
Benidipine hydrochloride (0.01-1 μM, 7 天) 通过增强磷酸化 Akt 促进小鼠内皮细胞分化。Benidipine hydrochloride (0.1-10 μM, 48 h) 在 G0/G1 和 G1/S 期均能明显抑制系膜细胞的增殖。
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