产品
编 号：F519133
分子式：C29H32Cl2N6.4H3O4P.4H2O
分子量：999.6
分子式：C29H32Cl2N6.4H3O4P.4H2O
分子量：999.6
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 915967-82-7
产品详情
生物活性：
Piperaquine tetraphosphate tetrahydrate is a bisquinoline antimalarial agent. Piperaquine tetraphosphate tetrahydrate can be used in antimalarial research in combination with Artemisinin.
体内研究：
Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice.Piperaquine (90 mg/kg; a single i.p.) exhibits the t1/2, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg?h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg?h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice.Animal Model:Male BALB/c mice (7 to 8 weeks) are inoculated with Plasmodium berghei parasites
Dosage:0, 10, 30, 90 mg/kg
Administration:A single i.p. administration
Result:The median survival time was 10 days at dose of 10 mg/kg.The median survival time was 54 days at dose of 30 mg/kg.All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg.
Animal Model:Male Swiss mice (6 weeks old)
Dosage:90 mg/kg (Pharmacokinetic Analysis)
Administration:A single i.p. administration
Result:t1/2=17.8 d; AUC=33.5 mg?h/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg.
Piperaquine tetraphosphate tetrahydrate is a bisquinoline antimalarial agent. Piperaquine tetraphosphate tetrahydrate can be used in antimalarial research in combination with Artemisinin.
体内研究：
Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice.Piperaquine (90 mg/kg; a single i.p.) exhibits the t1/2, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg?h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg?h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice.Animal Model:Male BALB/c mice (7 to 8 weeks) are inoculated with Plasmodium berghei parasites
Dosage:0, 10, 30, 90 mg/kg
Administration:A single i.p. administration
Result:The median survival time was 10 days at dose of 10 mg/kg.The median survival time was 54 days at dose of 30 mg/kg.All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg.
Animal Model:Male Swiss mice (6 weeks old)
Dosage:90 mg/kg (Pharmacokinetic Analysis)
Administration:A single i.p. administration
Result:t1/2=17.8 d; AUC=33.5 mg?h/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg.
产品资料
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