产品
编 号:F518454
分子式:C25H21N3O6
分子量:459.45
产品类型
结构图
CAS No: 915360-05-3
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生物活性:
Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities.
体外研究:
Indimitecan (LMP776) (0-100 μM) shows antiproliferative potencies against various human cancer cell lines, with mean-graph midpoint (MGM) of 0.079 ± 0.023 μM.Indimitecan shows potent DNA cleavage due to Top1 inhibition.Indimitecan can be substrates for metabolic ketone reductases.