产品
编 号：F518440
分子式：C26H26N2O7
分子量：478.49
分子式：C26H26N2O7
分子量：478.49
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 915303-09-2
产品详情
生物活性：
Indotecan (LMP-400), an indenoisoquinoline derivative, is a potent Topoisomerase I inhibitor, with IC50s of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan prevents the relaxation of supercoiled DNA and can be used for the research of visceral leishmaniasis.
体内研究：
Indotecan (2.5 mg/kg; 腹腔注射每 2 天一次共 15 天) 减轻了内脏利什曼病小鼠的脾脏和肝脏中的寄生负担。Animal Model:Female BALB/c mice (4-6 weeks) were infected with metacyclic parasites intravenously through the tail vein
Dosage:2.5 mg/kg body weight per injection
Administration:Intraperitoneally every 2 days for 15 days (total, eight doses)
Result:A drastic reduction of the number of transforming amastigotes recovered from the target organs of drug-treated animals was observed.
体外研究：
Indotecan (48 h) 抑制 L. infantum 前鞭毛体、离体感染的脾细胞和未感染的脾细胞的 IC50 值分别为 0.10 μM，0.10 μM，和 57.16 μM。Indotecan (1.1-90 μM; 30 min) 诱导 TopI-DNA 共价配合物，并抑制 L. infantum 培养物中 DNA 合成。
Indotecan (LMP-400), an indenoisoquinoline derivative, is a potent Topoisomerase I inhibitor, with IC50s of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan prevents the relaxation of supercoiled DNA and can be used for the research of visceral leishmaniasis.
体内研究：
Indotecan (2.5 mg/kg; 腹腔注射每 2 天一次共 15 天) 减轻了内脏利什曼病小鼠的脾脏和肝脏中的寄生负担。Animal Model:Female BALB/c mice (4-6 weeks) were infected with metacyclic parasites intravenously through the tail vein
Dosage:2.5 mg/kg body weight per injection
Administration:Intraperitoneally every 2 days for 15 days (total, eight doses)
Result:A drastic reduction of the number of transforming amastigotes recovered from the target organs of drug-treated animals was observed.
体外研究：
Indotecan (48 h) 抑制 L. infantum 前鞭毛体、离体感染的脾细胞和未感染的脾细胞的 IC50 值分别为 0.10 μM，0.10 μM，和 57.16 μM。Indotecan (1.1-90 μM; 30 min) 诱导 TopI-DNA 共价配合物，并抑制 L. infantum 培养物中 DNA 合成。
产品资料
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