产品
编 号：F518230
分子式：C42H56N2O10
分子量：748.9
分子式：C42H56N2O10
分子量：748.9
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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结构图
CAS No: 914805-33-7
产品详情
生物活性：
Shield-1 (Shld1) is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize proteins tagged with a mutated FKBP12-derived destabilization domain (DD).
体外研究：
Shield-1 (0.1 nM-1 μM) 响应不稳定结构域的表征。当将 mtFKBP 去稳定域与 TRPV5 或 YFP 融合时，Shield-1 (1 μM；24 小时) 处理在 TRPV5 和 YFP 上均表现出优异的表达，并导致 mtFKBP-TRPV5 形成功能性离子通道。
Shield-1 (Shld1) is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize proteins tagged with a mutated FKBP12-derived destabilization domain (DD).
体外研究：
Shield-1 (0.1 nM-1 μM) 响应不稳定结构域的表征。当将 mtFKBP 去稳定域与 TRPV5 或 YFP 融合时，Shield-1 (1 μM；24 小时) 处理在 TRPV5 和 YFP 上均表现出优异的表达，并导致 mtFKBP-TRPV5 形成功能性离子通道。
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