产品
编 号:F518021
分子式:C206H305N51O66
分子量:4551.93
产品类型
结构图
CAS No: 914454-00-5
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产品详情
生物活性:
Enfuvirtide (T20; DP178) acetate is an anti-HIV-1 fusion inhibitor peptide.
体内研究:
Enfuvirtide has a T1/2 of 3.8 h.
体外研究:
A cell-cell fusion assay reveals that the effective concentration for achieving 50% inhibition (IC50) of Enfuvirtide is 23 ± 6 nM.IFN-λs (1, 2, or 3) or the antiretrovirals (AZT, Efavirenz, Indinavir, and Enfuvirtide) significantly inhibita the expression of HIV p24 antigen and Gag gene in macrophages. IFN-λs (1, 2, or 3) also enhanced the anti-HIV (Bal) effect of AZT, Efavirenz, Indinavir, and Enfuvirtide.