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编 号：F517543
分子式：C17H20F2N3O6PS
分子量：463.39
分子式：C17H20F2N3O6PS
分子量：463.39
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CAS No: 913842-25-8
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生物活性：
Lu AA47070 is a phosphonooxymethylene prodrug of a potent and selective Adenosine A2A receptor antagonist. Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade.
体内研究：
Lu AA47070 (3.75、7.5、15、30 mg/kg；腹腔注射) 逆转由亚慢性给药 D2 拮抗剂匹莫齐特（1.0 mg/kg；腹腔注射）引起的下颌颤动、僵直和运动抑制。Animal Model:Male Sprague Dawley rats
Dosage:3.75, 7.5, 15, 30 mg/kg
Administration:I.p.
Result:Reversed the tremulous jaw movements, catalepsy, and locomotor suppression induced by subchronic administration of the D2 antagonist pimozide (1.0 mg/kg IP).
Lu AA47070 is a phosphonooxymethylene prodrug of a potent and selective Adenosine A2A receptor antagonist. Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade.
体内研究：
Lu AA47070 (3.75、7.5、15、30 mg/kg；腹腔注射) 逆转由亚慢性给药 D2 拮抗剂匹莫齐特（1.0 mg/kg；腹腔注射）引起的下颌颤动、僵直和运动抑制。Animal Model:Male Sprague Dawley rats
Dosage:3.75, 7.5, 15, 30 mg/kg
Administration:I.p.
Result:Reversed the tremulous jaw movements, catalepsy, and locomotor suppression induced by subchronic administration of the D2 antagonist pimozide (1.0 mg/kg IP).
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