产品
编 号：F517411
分子式：C29H23N7O2S2
分子量：565.67
分子式：C29H23N7O2S2
分子量：565.67
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规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 913822-46-5
产品详情
生物活性：
SC75741 is a broad and efficient NF-κB inhibitor with an IC50 of 200 nM for p65. SC75741 blocks influenza viruses (IV) replication. SC75741 impairs DNA binding of the NF-κB subunit p65, resulting in reduced expression of cytokines, chemokines, and pro-apoptotic factors. SC75741 subsequently inhibits caspase activation and blocks caspase-mediated nuclear export of viral ribonucleoproteins.
体内研究：
SC75741 (intraperitoneal injection; 15?mg/kg; for 2 days) leads to a reduced propagation of the H5N1 virus mRNA by 90% in the lungs of infected mice.The plasma-levels of SC74751 (intravenously of 5 mg/kg and intraperitoneally of 15 mg/kg; for 3.5 and 6 hours) after i.v. administration decreases mono-exponentially and half-life is roughly 40 min. After i.p. administration, elimination of SC75741 seems to be limited by a slow uptake from the peritoneum and a half-life of 55 min is observed.Animal Model:Inbred female C57BL/6 mice at the age of 6-8 weeks
Dosage:15?mg/kg
Administration:Intraperitoneal injection; for 2 days
Result:Reduced the amount of viral mRNA by 90%.
Animal Model:Inbred female C57BL/6 mice at the age of 6-8 weeks
Dosage:5 mg/kg or 15 mg/kg
Administration:Intravenously of 5 mg/kg and intraperitoneally of 15 mg/kg; 3.5 and 6 hours
Result:Half-life was roughly 40 min and 55 min for i.v. and i.p. administration, respectively.
体外研究：
SC75741 (5 μM; 24-96 hours) inhibits long-term A549 cells proliferation.SC75741 (1-10 μM; 5.5-65 hours) reduces A549 cells viability in a concentration-dependent manner indicating a cytostatic effect for A549 cells within a time frame of about 50 and 65?hours.SC75741 (5 μM; 24 hours) strongly inhibits cleavage of the effector caspase 3 induced upon H7N7-infection.
SC75741 is a broad and efficient NF-κB inhibitor with an IC50 of 200 nM for p65. SC75741 blocks influenza viruses (IV) replication. SC75741 impairs DNA binding of the NF-κB subunit p65, resulting in reduced expression of cytokines, chemokines, and pro-apoptotic factors. SC75741 subsequently inhibits caspase activation and blocks caspase-mediated nuclear export of viral ribonucleoproteins.
体内研究：
SC75741 (intraperitoneal injection; 15?mg/kg; for 2 days) leads to a reduced propagation of the H5N1 virus mRNA by 90% in the lungs of infected mice.The plasma-levels of SC74751 (intravenously of 5 mg/kg and intraperitoneally of 15 mg/kg; for 3.5 and 6 hours) after i.v. administration decreases mono-exponentially and half-life is roughly 40 min. After i.p. administration, elimination of SC75741 seems to be limited by a slow uptake from the peritoneum and a half-life of 55 min is observed.Animal Model:Inbred female C57BL/6 mice at the age of 6-8 weeks
Dosage:15?mg/kg
Administration:Intraperitoneal injection; for 2 days
Result:Reduced the amount of viral mRNA by 90%.
Animal Model:Inbred female C57BL/6 mice at the age of 6-8 weeks
Dosage:5 mg/kg or 15 mg/kg
Administration:Intravenously of 5 mg/kg and intraperitoneally of 15 mg/kg; 3.5 and 6 hours
Result:Half-life was roughly 40 min and 55 min for i.v. and i.p. administration, respectively.
体外研究：
SC75741 (5 μM; 24-96 hours) inhibits long-term A549 cells proliferation.SC75741 (1-10 μM; 5.5-65 hours) reduces A549 cells viability in a concentration-dependent manner indicating a cytostatic effect for A549 cells within a time frame of about 50 and 65?hours.SC75741 (5 μM; 24 hours) strongly inhibits cleavage of the effector caspase 3 induced upon H7N7-infection.
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