产品
编 号：F517389
分子式：C16H25ClN2O
分子量：296.84
分子式：C16H25ClN2O
分子量：296.84
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
25mg
320
In-stock
50mg
528
In-stock
100mg
960
In-stock
200mg
1560
In-stock
结构图
CAS No: 91374-20-8
产品详情
生物活性：
Ropinirole (SKF 101468) hydrochloride is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole hydrochloride has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole hydrochloride has no affinity for the D1 receptors. Ropinirole hydrochloride has the potential for Parkinson's disease.
体内研究：
Ropinirole (0.1-10 mg/kg; i.p.) decreases intracranial self-stimulation (ICSS) thresholds and induces anxiolytic- and antidepressive-like effects without affecting motor activity or spatial memory.Animal Model:Male Sprague–Dawley rats weighing 220-350 g
Dosage:0.1, 1 or 10 mg/kg
Administration:i.p.
Result:Decreased ICSS thresholds and induced anxiolytic- and antidepressive-like effects without affecting motor activity or spatial memory.
体外研究：
Ropinirole hydrochloride has affinity for D3 receptors of 10-20 fold higher than the D2 and D4 receptors. Ropinirole hydrochloride is weakly active at alpha 2-adrenoceptors and 5-HT2 receptors but inactive at 5-HT1, benzodiazepine and gamma-aminobutyric acid receptors or alpha 1 and beta-adrenoceptors.
Ropinirole (SKF 101468) hydrochloride is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole hydrochloride has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole hydrochloride has no affinity for the D1 receptors. Ropinirole hydrochloride has the potential for Parkinson's disease.
体内研究：
Ropinirole (0.1-10 mg/kg; i.p.) decreases intracranial self-stimulation (ICSS) thresholds and induces anxiolytic- and antidepressive-like effects without affecting motor activity or spatial memory.Animal Model:Male Sprague–Dawley rats weighing 220-350 g
Dosage:0.1, 1 or 10 mg/kg
Administration:i.p.
Result:Decreased ICSS thresholds and induced anxiolytic- and antidepressive-like effects without affecting motor activity or spatial memory.
体外研究：
Ropinirole hydrochloride has affinity for D3 receptors of 10-20 fold higher than the D2 and D4 receptors. Ropinirole hydrochloride is weakly active at alpha 2-adrenoceptors and 5-HT2 receptors but inactive at 5-HT1, benzodiazepine and gamma-aminobutyric acid receptors or alpha 1 and beta-adrenoceptors.
产品资料
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