产品
编 号：F517310
分子式：C25H27N3O2S
分子量：433.57
分子式：C25H27N3O2S
分子量：433.57
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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5mg
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10mg
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50mg
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100mg
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200mg
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500mg
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结构图
CAS No: 913611-97-9
产品详情
生物活性：
Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM).
体内研究：
Brexpiprazole (0-0.1 mg/kg；口服；一次) 改善小鼠的社会认知缺陷。Animal Model:Male C57BL/6NCrSlc mice, Dizocilpine (0.1 mg/kg) (HY-15084B) induced social recognition deficits
Dosage:0.01, 0.03 and 0.1 mg/kg
Administration:Oral administration, once
Result:Significantly ameliorated Dizocilpine-induced social recognition deficits, without sedation or a reduction of exploratory behavior.
体外研究：
Brexpiprazole (0-1.0 μM，4 天) 以剂量依赖性方式增强 PC12 细胞中 NGF 诱导的神经突生长。
Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM).
体内研究：
Brexpiprazole (0-0.1 mg/kg；口服；一次) 改善小鼠的社会认知缺陷。Animal Model:Male C57BL/6NCrSlc mice, Dizocilpine (0.1 mg/kg) (HY-15084B) induced social recognition deficits
Dosage:0.01, 0.03 and 0.1 mg/kg
Administration:Oral administration, once
Result:Significantly ameliorated Dizocilpine-induced social recognition deficits, without sedation or a reduction of exploratory behavior.
体外研究：
Brexpiprazole (0-1.0 μM，4 天) 以剂量依赖性方式增强 PC12 细胞中 NGF 诱导的神经突生长。
产品资料
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