产品
编 号：F516239
分子式：C29H33Cl2N3O3
分子量：542.5
分子式：C29H33Cl2N3O3
分子量：542.5
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 911295-24-4
产品详情
生物活性：
MPP dihydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP dihydrochloride induces significant apoptosis in the endometrial cancer and oLE cell lines. MPP dihydrochloride reverses the positive effects of beta-estradiol. MPP dihydrochloride has mixed agonist/antagonist action on murine uterine ERalpha in vivo.
体内研究：
MPP dihydrochloride (20 μg/kg 或 200 μg/kg ) 导致前脉冲抑制百分比 (PPI) 呈剂量依赖性衰减。Animal Model:Male C57BL/6N mice at the age of 9-10 weeks
Dosage:Low dose (20 μg/kg body weight) or high dose (200 μg/kg body weight)
Administration:Administered subcutaneously (s.c.) injected; injection volume of 5 mL/kg; 60 min before PPI testing
Result:Led to a dose-dependent attenuation of percent PPI. Pretreatment with 200 μg/kg reduced the mean percent PPI scores by ~30%.
体外研究：
MPP dihydrochloride (1、5、10、25、50 和 100 μM；24 小时) 在 RL95-2 细胞中降低细胞活力，IC50 值为 20.01 μM。 MPP dihydrochloride 在浓度为 10 μM 时在 RL95-2 细胞中表现出抗增殖活性。 MPP dihydrochloride (20 μM；24 h) 降低磷酸化ERα，但它不会改变 Akt 的磷酸化。MPP dihydrochloride 降低 p-ERα/ERα 的比率。
MPP dihydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP dihydrochloride induces significant apoptosis in the endometrial cancer and oLE cell lines. MPP dihydrochloride reverses the positive effects of beta-estradiol. MPP dihydrochloride has mixed agonist/antagonist action on murine uterine ERalpha in vivo.
体内研究：
MPP dihydrochloride (20 μg/kg 或 200 μg/kg ) 导致前脉冲抑制百分比 (PPI) 呈剂量依赖性衰减。Animal Model:Male C57BL/6N mice at the age of 9-10 weeks
Dosage:Low dose (20 μg/kg body weight) or high dose (200 μg/kg body weight)
Administration:Administered subcutaneously (s.c.) injected; injection volume of 5 mL/kg; 60 min before PPI testing
Result:Led to a dose-dependent attenuation of percent PPI. Pretreatment with 200 μg/kg reduced the mean percent PPI scores by ~30%.
体外研究：
MPP dihydrochloride (1、5、10、25、50 和 100 μM；24 小时) 在 RL95-2 细胞中降低细胞活力，IC50 值为 20.01 μM。 MPP dihydrochloride 在浓度为 10 μM 时在 RL95-2 细胞中表现出抗增殖活性。 MPP dihydrochloride (20 μM；24 h) 降低磷酸化ERα，但它不会改变 Akt 的磷酸化。MPP dihydrochloride 降低 p-ERα/ERα 的比率。
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