产品
编 号：F516009
分子式：C16H26N2O6S2
分子量：406.52
分子式：C16H26N2O6S2
分子量：406.52
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 910627-26-8
产品详情
生物活性：
CMX-2043 is a novel analogue of α-Lipoic Acid (HY-N0492). CMX-2043 is effective in antioxidant effect, activation of insulin receptor kinase, soluble tyrosine kinase, and Akt phosphorylation. CMX-2043 shows protection against ischemia-reperfusion injury (IRI) in rat model.
体内研究：
CMX-2043 (50-200 mg/kg, 5 mL; p.o.; single dose) reduces myocardial ischemia-reperfusion injury (IRI) as measured by the myocardial infarct to area at risk (MI-AR) ratio and the incidence of arrhythmia.Animal Model:Ischemia-reperfusion injury (IRI) model in Sprague Dawley rats
Dosage:50, 100, and 200 mg/kg; 5 mL of normal saline solution containing 2% vanilla extract as flavoring
Administration:Oral gavage; single dose; induced IRI 30-60 min after treatment
Result:Induced arrhythmia and mortality of rats with reducing the ratio of myocardial infarct to area at risk.
体外研究：
CMX-2043 (15-250 mM; 10 min) has great peroxyl radical absorbance capacity.CMX-2043 (1.5 μM) weakly inhibits spleen tyrosine kinase (Syk) and tunica interna endothelial cell kinase (Tie2).CMX-2043 (50 μM; 45 min) activates Akt phosporylation via PI3K pathway in A549 cells.CMX-2043 (2.5 mM; 30 min) diminishes the rise in cytosolic calcium in a concentration-dependent manner in CHO-M1-WT3 cells.
CMX-2043 is a novel analogue of α-Lipoic Acid (HY-N0492). CMX-2043 is effective in antioxidant effect, activation of insulin receptor kinase, soluble tyrosine kinase, and Akt phosphorylation. CMX-2043 shows protection against ischemia-reperfusion injury (IRI) in rat model.
体内研究：
CMX-2043 (50-200 mg/kg, 5 mL; p.o.; single dose) reduces myocardial ischemia-reperfusion injury (IRI) as measured by the myocardial infarct to area at risk (MI-AR) ratio and the incidence of arrhythmia.Animal Model:Ischemia-reperfusion injury (IRI) model in Sprague Dawley rats
Dosage:50, 100, and 200 mg/kg; 5 mL of normal saline solution containing 2% vanilla extract as flavoring
Administration:Oral gavage; single dose; induced IRI 30-60 min after treatment
Result:Induced arrhythmia and mortality of rats with reducing the ratio of myocardial infarct to area at risk.
体外研究：
CMX-2043 (15-250 mM; 10 min) has great peroxyl radical absorbance capacity.CMX-2043 (1.5 μM) weakly inhibits spleen tyrosine kinase (Syk) and tunica interna endothelial cell kinase (Tie2).CMX-2043 (50 μM; 45 min) activates Akt phosporylation via PI3K pathway in A549 cells.CMX-2043 (2.5 mM; 30 min) diminishes the rise in cytosolic calcium in a concentration-dependent manner in CHO-M1-WT3 cells.
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