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编 号:F515362
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CAS No: 909395-70-6
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生物活性:
Romosozumab is a humanized monoclonal anti-sclerostin antibody, it promotes bone formation and inhibits bone resorption by inhibiting sclerostin. Romosozumab can be used for the research of osteoporosis.
体内研究:
Romosozumab (30 mg/kg; s.c. twice a week for 10 weeks) converts trabecular rods into trabecular plates in cynomolgus monkeys.Romosozumab (3 and 30 mg/kg; s.c. once a week for 6 or 12 months) improves bone mass,architecture, and bone strength, and maintains bone quality at the same time in mature cynomolgus monkeys with 4 months post-ovariectomy.Animal Model:Male cynomolgus monkeys
Dosage:30 mg/kg
Administration:Subcutaneous injection; 30 mg/kg twice a week for 10 weeks
Result:Increased bone formation and plate-like trabecular morphology, and improved mechanical performance.