产品
编 号：F513788
分子式：C22H27F3O4S
分子量：444.51
分子式：C22H27F3O4S
分子量：444.51
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CAS No: 90566-53-3
产品详情
生物活性：
Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC50 value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells.
体内研究：
Fluticasone (1 mg/kg; intranasal dropping; 7 d) suppressesrhinovirus-induced airways inflammation in vivo but also impairs anti-viral immune responses and increases viral titres, leading to mucus hypersecretion.Animal Model:C57BL/6 mice
Dosage:1 mg/kg
Administration:Intranasal dropping; 1 h before infection with rhinovirus 1B; 7 days
Result:Suppressed BAL neutrophil numbers and inhibited rhinovirus-induced airway inflammation.
体外研究：
Fluticasone (0-10 μM, 2 h) inhibits U2OS cells growth with an EC50 value of 99 nM.Fluticasone (10-1000 nM, 48 h) decreases HRV-induced mucin production and involves in modulation of SPDEF-regulated genes and extracellular ATP release.
Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC50 value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells.
体内研究：
Fluticasone (1 mg/kg; intranasal dropping; 7 d) suppressesrhinovirus-induced airways inflammation in vivo but also impairs anti-viral immune responses and increases viral titres, leading to mucus hypersecretion.Animal Model:C57BL/6 mice
Dosage:1 mg/kg
Administration:Intranasal dropping; 1 h before infection with rhinovirus 1B; 7 days
Result:Suppressed BAL neutrophil numbers and inhibited rhinovirus-induced airway inflammation.
体外研究：
Fluticasone (0-10 μM, 2 h) inhibits U2OS cells growth with an EC50 value of 99 nM.Fluticasone (10-1000 nM, 48 h) decreases HRV-induced mucin production and involves in modulation of SPDEF-regulated genes and extracellular ATP release.
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