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CAS No: 9046-40-6
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生物活性：
Pectic acid (Methyl protopectin), a polygalacturonic acid, induces cell apoptosis and necrosis in pituitary tumor cells. Pectic acid can be used in the research of cancers and autoimmune disease.
体内研究：
Pectic acid (25 and 100 mg/kg, oral gavage) increases colon length, downregulates disease activity index, histopathological score and proinflammatory cytokine levels in Ulcerative colitis (UC) mice.Pectic acid (6.25 and 12.5 mg/kg, intravenous injection) rescues the reduction in colon length in UC mice.Animal Model:Ulcerative colitis (UC) mice
Dosage:25, 100 mg/kg
Administration:Oral gavage
Result:Exhibited the longest colon, lowest DAI, and minimum histopathological score. Decreased the proinflammatory cytokines in the colonic tissue of UC mice.
Animal Model:Ulcerative colitis (UC) mice
Dosage:6.25, 12.5 mg/kg
Administration:Intravenous injection
Result:Decreased the spleen and thymus index.Restored the Th17/Treg balance in the spleen and lamina propria of UC mice. Improved the gut microbiota composition.
体外研究：
Pectic acid (2.5-100 μg/mL, 30 min) stimulates the release of prolactin (PRL) in GH3/B6 cells, without affecting the viability of cells.Pectic acid (100 μg/mL-5 mg/mL, 6-48 h) increases cell death and DNA damage in GH3/B6 cells, detected by MTT assay and AO/EB staining.Pectic acid (100 μg/mL-1 mg/mL, 24 h) induces apoptosis in GH3/B6 cells in a dose-dependent manner.Pectic acid (2.5-5 mg/mL, 24 h) induces necrosis in GH3/B6 cells, confirmed by PI staining.
Pectic acid (Methyl protopectin), a polygalacturonic acid, induces cell apoptosis and necrosis in pituitary tumor cells. Pectic acid can be used in the research of cancers and autoimmune disease.
体内研究：
Pectic acid (25 and 100 mg/kg, oral gavage) increases colon length, downregulates disease activity index, histopathological score and proinflammatory cytokine levels in Ulcerative colitis (UC) mice.Pectic acid (6.25 and 12.5 mg/kg, intravenous injection) rescues the reduction in colon length in UC mice.Animal Model:Ulcerative colitis (UC) mice
Dosage:25, 100 mg/kg
Administration:Oral gavage
Result:Exhibited the longest colon, lowest DAI, and minimum histopathological score. Decreased the proinflammatory cytokines in the colonic tissue of UC mice.
Animal Model:Ulcerative colitis (UC) mice
Dosage:6.25, 12.5 mg/kg
Administration:Intravenous injection
Result:Decreased the spleen and thymus index.Restored the Th17/Treg balance in the spleen and lamina propria of UC mice. Improved the gut microbiota composition.
体外研究：
Pectic acid (2.5-100 μg/mL, 30 min) stimulates the release of prolactin (PRL) in GH3/B6 cells, without affecting the viability of cells.Pectic acid (100 μg/mL-5 mg/mL, 6-48 h) increases cell death and DNA damage in GH3/B6 cells, detected by MTT assay and AO/EB staining.Pectic acid (100 μg/mL-1 mg/mL, 24 h) induces apoptosis in GH3/B6 cells in a dose-dependent manner.Pectic acid (2.5-5 mg/mL, 24 h) induces necrosis in GH3/B6 cells, confirmed by PI staining.
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