产品
编 号：F512106
分子式：C25H28N4O2
分子量：416.52
分子式：C25H28N4O2
分子量：416.52
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CAS No: 902279-44-1
产品详情
生物活性：
CPUY074020 is a potent and oral bioavailable inhibitor of histone methyltransferase G9a, with an IC50 of 2.18 μM. CPUY074020 possesses anti-proliferative activity.
体内研究：
CPUY074020 exhibits reasonable PK properties, with an oral bioavailability of 55.5% and a T1/2 value of 4.0 hours at an oral dose of 10 mg/kg.Animal Model:Mice
Dosage:10 mg/kg
Administration:Oral administration
Result:t1/2=4.0 hours
体外研究：
CPUY074020 (2-8μM; 24 hours) induces cell death through apoptosis.CPUY074020 (2.5-10μM ; 48 hours) dose-dependently de-regulates H3K9 trimethylation.
CPUY074020 is a potent and oral bioavailable inhibitor of histone methyltransferase G9a, with an IC50 of 2.18 μM. CPUY074020 possesses anti-proliferative activity.
体内研究：
CPUY074020 exhibits reasonable PK properties, with an oral bioavailability of 55.5% and a T1/2 value of 4.0 hours at an oral dose of 10 mg/kg.Animal Model:Mice
Dosage:10 mg/kg
Administration:Oral administration
Result:t1/2=4.0 hours
体外研究：
CPUY074020 (2-8μM; 24 hours) induces cell death through apoptosis.CPUY074020 (2.5-10μM ; 48 hours) dose-dependently de-regulates H3K9 trimethylation.
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