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编 号:F511831
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CAS No: 9015-68-3
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生物活性:
L-Asparaginase (L-ASNase) is a deamidating enzyme that catalyses the hydrolysis of L-asparagine and L-glutamine, and can be used for the research of acute lymphoblastic leukemia. L-Asparaginase depletes L-asparagine from plasma resulting in inhibition of RNA and DNA synthesis with the subsequent blastic cell apoptosis.
体外研究:
L-Asparaginase 对 AML 母细胞和 LSC 亚群具有细胞毒性作用。 L-Asparaginase 对 CD34+CD38+ 和 CD34+CD38+ LSC 部分、MSC 和单核细胞/巨噬细胞部分抵消了这种影响。