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编 号:F511767
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Pyruvate carboxylase is a biotin-containing enzyme that catalyzes the HCO3? and MgATP dependent carboxylation of pyruvate to form oxaloacetate. Pyruvate carboxylase plays an essential role in controlling whole-body energetics through regulation of gluconeogenesis in the liver, synthesis of fatty acids in adipocytes, and insulin secretion in pancreatic β cells.
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