产品
编 号：F511492
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 9008-30-4
产品详情
生物活性：
Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL). Lysophosphatidylcholines induces cell injury, the production of IL-1β and apoptosis. Lysophosphatidylcholines has a proactive effect on sepsis.
体内研究：
Lysophosphatidylcholines (0.1-20 mg/kg，口服，单次剂量) 对败血症诱导的白化 ICR 小鼠死亡具有保护作用。Lysophosphatidylcholines (0.1-20 mg/kg，口服，单次剂量) 可增强细菌清除，阻断 CLP 诱导的中性粒细胞失活，提高中性粒细胞的杀菌活性。Animal Model:Albino ICR mice
Dosage:0.1 mg/kg, 1 mg/kg, 10 mg/kg, 20 mg/kg
Administration:Oral
Result:Provided significant protection against cecal ligation and puncture (CLP)-induced lethality at a dose of 1 mg/kg.
体外研究：
Lysophosphatidylcholine (3-100 μM, 24 h)降低 HUVEC 细胞活力。Lysophosphatidylcholines (12.5μM, 4 h) 上调人外周血单核细胞 IL-1β 的基因表达。Lysophosphatidylcholines (75μM, 24 h) 通过 p38-丝裂原活化蛋白激酶依赖机制诱导 HUVEC 凋亡。
Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL). Lysophosphatidylcholines induces cell injury, the production of IL-1β and apoptosis. Lysophosphatidylcholines has a proactive effect on sepsis.
体内研究：
Lysophosphatidylcholines (0.1-20 mg/kg，口服，单次剂量) 对败血症诱导的白化 ICR 小鼠死亡具有保护作用。Lysophosphatidylcholines (0.1-20 mg/kg，口服，单次剂量) 可增强细菌清除，阻断 CLP 诱导的中性粒细胞失活，提高中性粒细胞的杀菌活性。Animal Model:Albino ICR mice
Dosage:0.1 mg/kg, 1 mg/kg, 10 mg/kg, 20 mg/kg
Administration:Oral
Result:Provided significant protection against cecal ligation and puncture (CLP)-induced lethality at a dose of 1 mg/kg.
体外研究：
Lysophosphatidylcholine (3-100 μM, 24 h)降低 HUVEC 细胞活力。Lysophosphatidylcholines (12.5μM, 4 h) 上调人外周血单核细胞 IL-1β 的基因表达。Lysophosphatidylcholines (75μM, 24 h) 通过 p38-丝裂原活化蛋白激酶依赖机制诱导 HUVEC 凋亡。
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