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CAS No: 9007-81-2
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Complete Freund's adjuvant (CFA) is an immunoadjuvant emulsified with antigen by its discoverer Jules T. Freund to enhance an animal's immune response to an antigen. Complete Freund's adjuvant (CFA) is also an inducer of the Th1 immune response and a ligand of TLRs. Complete Freund's adjuvant (CFA) contains heat-killed inactive tuberculosis bacilli and consists of a paraffin oil-in-water emulsion. Complete Freund's adjuvant (CFA) stimulates a strong and durable immune response and can be used to induce persistent inflammatory pain models in mice, experimental autoimmune myocarditis (EAM) models, and more. Incomplete Freund's adjuvant (IFA) (HY-153808A) is another type of Freund's Adjuvant that stimulates a weaker immune response.
体内研究：
.f12{font-size: 12px;}.fwb{font-weight: bold;}.lh22{line-height: 22px;;}.lh23 {line-height: 23px;}.pl13{padding-left: 13px;;}.part {margin-top: 18px;}.mold-first-tit {width: 100%;height: 44px;line-height: 44px;background: #F9F7FB;border-bottom: 1px solid #EBE4F6;padding-left: 16px;box-sizing: border-box;margin-bottom: 17px;}.mold-second-tit:before {content:"";width: 6px;height: 6px;display: inline-block;border-radius: 50%;background: rgba(255,102,0,0.4);margin-right: 12px;position: relative;top: -3px;}.lft-border {border-left: 1px dotted #EBE4F6;padding-right: 12px;margin-left: 3px;box-sizing: border-box;padding-bottom: 12px;}/* .part.dec:last-child {border-bottom: 0;} */.dec {margin: 10px 15px 0;padding-bottom: 10px;border-bottom: 1px dashed #EBE4F6;}.btm-border {border-left: 1px dashed #EBE4F6;}.text-bg {margin-top: 10px;background: #FFFBF1;padding: 14px;border-bottom: 0;position: relative;}.text-note-bg {margin-top: 10px;background: #FFFDF7;padding: 12px;border-bottom: 0;position: relative;}.text-note {width: 51px;height: 20px;line-height: 20px;background: #FFE2AA;text-align: center;border-radius: 0 0 8px 0;position: absolute;top: 0;left: 0;}.text-note-dec {margin-top: 15px;;} Complete Freund's adjuvant (CFA) 可在 TLR 缺陷小鼠中引发针对 T 细胞依赖性抗原的强烈抗体反应，这是一种 T 细胞依赖性抗原特异性抗体反应。 Complete Freund's adjuvant (CFA) 与肌球蛋白或致心肌肽乳化，皮下注射雄性小鼠 (两次注射，间隔 7 天)，诱导实验性自身免疫性心肌炎 (EAM) 小鼠模型。Complete Freund's adjuvant (CFA) 加甲状腺球蛋白可诱导甲状腺炎，而 Incomplete Freund's adjuvant (IFA) (HY-153808A) 不足以作为甲状腺病变的佐剂。Complete Freund's adjuvant (CFA) 注射到 C57BL/6J 小鼠的后爪足底区域，诱导炎症性疼痛小鼠模型。Complete Freund's adjuvant (CFA) 对侧注射可导致腹侧苍白球 (VP) 胆碱能 (ChAT) 系统的神经元的光遗传学抑制，并显着减少光抑制侧 VP 中 c-Fos 阳性神经元的数量。Complete Freund's adjuvant (CFA) 在正常大鼠中的血浆清除率低 (22%)。 Complete Freund's adjuvant (CFA) 的血浆清除率低 (22%)。1. 诱导神经性疼痛致病原理Complete Freund's adjuvant (CFA) 在体内释放的炎症介质 TNF-α 和 IL-6 可以激活周围神经末梢并作用于痛觉神经末梢，导致神经性疼痛。 具体造模方法Mice: C57BL/6J • male • 8-week-oldAdministration: 20 μl • s.c. • onceNote(1) 在小鼠后爪足底区注射不稀释的完全弗氏佐剂 (CFA)。(2) 检测注射 CFA 前及注射后 24、48、72 小时双后爪 PWT、PWL。造模成功指标行为观测：检测撤爪阈值 (PWT) 和爪子收缩潜伏期 (PWL)。相关产品:Galantamine (HY-76299)拮抗产品: Mecamylamine (HY-B1395A) Animal Model:A/J, BALB/c, and IL6KO BALB/c male mice
Dosage:
Administration:Subcutaneous Injectionon (sc); injected at days 0 and 7. EAM severity was analyzed by histology on day 21 (Repeated administration of CFA to animals can cause multiple injection-site effects, the most often observed are on site granulomas and pain)
Result:Increased the relative proportion of CD11b+F4/80?monocytes and CD11b+Gr1+ granulocytes.Expanded monocytes in the heart and in the spleen and those monocytes in the spleen make less IL-10 as well as more IL-6.
体外研究：
Complete Freund's adjuvant (CFA) 含有多种微生物 TLR 配体 (如 TLR 2、4 和 9)，是 Th1 型免疫反应的有效诱导剂。
Complete Freund's adjuvant (CFA) is an immunoadjuvant emulsified with antigen by its discoverer Jules T. Freund to enhance an animal's immune response to an antigen. Complete Freund's adjuvant (CFA) is also an inducer of the Th1 immune response and a ligand of TLRs. Complete Freund's adjuvant (CFA) contains heat-killed inactive tuberculosis bacilli and consists of a paraffin oil-in-water emulsion. Complete Freund's adjuvant (CFA) stimulates a strong and durable immune response and can be used to induce persistent inflammatory pain models in mice, experimental autoimmune myocarditis (EAM) models, and more. Incomplete Freund's adjuvant (IFA) (HY-153808A) is another type of Freund's Adjuvant that stimulates a weaker immune response.
体内研究：
.f12{font-size: 12px;}.fwb{font-weight: bold;}.lh22{line-height: 22px;;}.lh23 {line-height: 23px;}.pl13{padding-left: 13px;;}.part {margin-top: 18px;}.mold-first-tit {width: 100%;height: 44px;line-height: 44px;background: #F9F7FB;border-bottom: 1px solid #EBE4F6;padding-left: 16px;box-sizing: border-box;margin-bottom: 17px;}.mold-second-tit:before {content:"";width: 6px;height: 6px;display: inline-block;border-radius: 50%;background: rgba(255,102,0,0.4);margin-right: 12px;position: relative;top: -3px;}.lft-border {border-left: 1px dotted #EBE4F6;padding-right: 12px;margin-left: 3px;box-sizing: border-box;padding-bottom: 12px;}/* .part.dec:last-child {border-bottom: 0;} */.dec {margin: 10px 15px 0;padding-bottom: 10px;border-bottom: 1px dashed #EBE4F6;}.btm-border {border-left: 1px dashed #EBE4F6;}.text-bg {margin-top: 10px;background: #FFFBF1;padding: 14px;border-bottom: 0;position: relative;}.text-note-bg {margin-top: 10px;background: #FFFDF7;padding: 12px;border-bottom: 0;position: relative;}.text-note {width: 51px;height: 20px;line-height: 20px;background: #FFE2AA;text-align: center;border-radius: 0 0 8px 0;position: absolute;top: 0;left: 0;}.text-note-dec {margin-top: 15px;;} Complete Freund's adjuvant (CFA) 可在 TLR 缺陷小鼠中引发针对 T 细胞依赖性抗原的强烈抗体反应，这是一种 T 细胞依赖性抗原特异性抗体反应。 Complete Freund's adjuvant (CFA) 与肌球蛋白或致心肌肽乳化，皮下注射雄性小鼠 (两次注射，间隔 7 天)，诱导实验性自身免疫性心肌炎 (EAM) 小鼠模型。Complete Freund's adjuvant (CFA) 加甲状腺球蛋白可诱导甲状腺炎，而 Incomplete Freund's adjuvant (IFA) (HY-153808A) 不足以作为甲状腺病变的佐剂。Complete Freund's adjuvant (CFA) 注射到 C57BL/6J 小鼠的后爪足底区域，诱导炎症性疼痛小鼠模型。Complete Freund's adjuvant (CFA) 对侧注射可导致腹侧苍白球 (VP) 胆碱能 (ChAT) 系统的神经元的光遗传学抑制，并显着减少光抑制侧 VP 中 c-Fos 阳性神经元的数量。Complete Freund's adjuvant (CFA) 在正常大鼠中的血浆清除率低 (22%)。 Complete Freund's adjuvant (CFA) 的血浆清除率低 (22%)。1. 诱导神经性疼痛致病原理Complete Freund's adjuvant (CFA) 在体内释放的炎症介质 TNF-α 和 IL-6 可以激活周围神经末梢并作用于痛觉神经末梢，导致神经性疼痛。 具体造模方法Mice: C57BL/6J • male • 8-week-oldAdministration: 20 μl • s.c. • onceNote(1) 在小鼠后爪足底区注射不稀释的完全弗氏佐剂 (CFA)。(2) 检测注射 CFA 前及注射后 24、48、72 小时双后爪 PWT、PWL。造模成功指标行为观测：检测撤爪阈值 (PWT) 和爪子收缩潜伏期 (PWL)。相关产品:Galantamine (HY-76299)拮抗产品: Mecamylamine (HY-B1395A) Animal Model:A/J, BALB/c, and IL6KO BALB/c male mice
Dosage:
Administration:Subcutaneous Injectionon (sc); injected at days 0 and 7. EAM severity was analyzed by histology on day 21 (Repeated administration of CFA to animals can cause multiple injection-site effects, the most often observed are on site granulomas and pain)
Result:Increased the relative proportion of CD11b+F4/80?monocytes and CD11b+Gr1+ granulocytes.Expanded monocytes in the heart and in the spleen and those monocytes in the spleen make less IL-10 as well as more IL-6.
体外研究：
Complete Freund's adjuvant (CFA) 含有多种微生物 TLR 配体 (如 TLR 2、4 和 9)，是 Th1 型免疫反应的有效诱导剂。
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