产品
编 号：F507421
分子式：C26H19F3N4O
分子量：460.45
分子式：C26H19F3N4O
分子量：460.45
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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5mg
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10mg
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50mg
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结构图
CAS No: 898563-00-3
产品详情
生物活性：
TP-10 is a selective PDE10A inhibitor with an IC50 value of 0.8 nM. TP-10 shows an antioxidant activity with IC50s of 31.72 and 16.04 μg/ml for DPPH and CUPRAC, respectively. TP-10 can be used for the research of neuropathy.
体内研究：
TP-10 (0.1-10 mg/kg; i.h. once) shows an effect on cyclic nucleotides.Animal Model:Male CD rats
Dosage:0.1, 0.32, 1.0, 3.2 and 10 mg/kg
Administration:Subcutaneous injection; 0.1-10 mg/kg once
Result:Dose- and time-dependently increased the levels of both cGMP and cAMP in striatal of mice. Increased pCREB-LI level first and returned to basal levels after injected for 3 hours at a dose of 3.2 mg/kg.
体外研究：
TP-10 (10 μg /mL; 24 h) affects total reactive oxygen species in human brain-derived cells (U-87 MG).
TP-10 is a selective PDE10A inhibitor with an IC50 value of 0.8 nM. TP-10 shows an antioxidant activity with IC50s of 31.72 and 16.04 μg/ml for DPPH and CUPRAC, respectively. TP-10 can be used for the research of neuropathy.
体内研究：
TP-10 (0.1-10 mg/kg; i.h. once) shows an effect on cyclic nucleotides.Animal Model:Male CD rats
Dosage:0.1, 0.32, 1.0, 3.2 and 10 mg/kg
Administration:Subcutaneous injection; 0.1-10 mg/kg once
Result:Dose- and time-dependently increased the levels of both cGMP and cAMP in striatal of mice. Increased pCREB-LI level first and returned to basal levels after injected for 3 hours at a dose of 3.2 mg/kg.
体外研究：
TP-10 (10 μg /mL; 24 h) affects total reactive oxygen species in human brain-derived cells (U-87 MG).
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