产品
编 号：F507261
分子式：C10H14O
分子量：150.22
分子式：C10H14O
分子量：150.22
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
400
In-stock
结构图
CAS No: 89-83-8
产品详情
生物活性：
Thymol is a TRPA1 agonist. Thymol induces cancer cell apoptosis. Thymol is the main monoterpene phenol occurring in essential oils isolated from plants belonging to the Lamiaceae family, and other plants such as those belonging to the Verbenaceae, Scrophulariaceae, Ranunculaceae and Apiaceae families. Thymol has antioxidant, anti-inflammatory, antibacterial and antifungal effects.
体内研究：
Thymol (75 mg/kg，腹膜内注射) 单独使用可抑制原位小鼠肺腺癌 (LUAD) 模型中 LUAD 的进展，与抗 PD-1 抗体 (10 mg/kg，腹膜内注射) 联合使用时使小鼠对抗 PD-1 抗体治疗变得敏感。Thymol (4.3 mM，溶于 50 μL 无菌盐水，瘤内注射，每隔一天) 在 Cal27 来源的异种移植小鼠中显示出抗肿瘤作用。Animal Model:orthotopic mouse LUAD model
Dosage:75 mg/kg for Thymol, 10 mg/kg for anti‐PD‐1 antibody
Administration:anti‐PD‐1 antibody: i.p., every 1 week from day 5 after tumor injection.Thymol: i.p., every 2 days from day 5 after tumor injection.
Result:Inhibited the progression of LUAD, and increased the survival of mice.Decreases IL4I1 level in tumors.Improved the efficacy of anti‐PD‐1 antibody.
体外研究：
Thymol (20 μM，24-48 小时) 可抑制 A549 细胞中的 IL4I1 表达 (24 小时) 并抑制芳烃受体 (AHR) 信号传导 (48 小时)。Thymol (5 μM，48 小时) 抑制 A549 细胞的上皮间质转化和运动活性。Thymol (0-600 μM，48 小时) 可抑制多种癌细胞类型 (Cal27、SCC4、SCC9、HeLa、H460、MDA-231 和 PC3 细胞) 的细胞增殖。Thymol (200 μg/mL) 诱导 A. flavus 中半胱天冬酶依赖性的分生孢子凋亡。
Thymol is a TRPA1 agonist. Thymol induces cancer cell apoptosis. Thymol is the main monoterpene phenol occurring in essential oils isolated from plants belonging to the Lamiaceae family, and other plants such as those belonging to the Verbenaceae, Scrophulariaceae, Ranunculaceae and Apiaceae families. Thymol has antioxidant, anti-inflammatory, antibacterial and antifungal effects.
体内研究：
Thymol (75 mg/kg，腹膜内注射) 单独使用可抑制原位小鼠肺腺癌 (LUAD) 模型中 LUAD 的进展，与抗 PD-1 抗体 (10 mg/kg，腹膜内注射) 联合使用时使小鼠对抗 PD-1 抗体治疗变得敏感。Thymol (4.3 mM，溶于 50 μL 无菌盐水，瘤内注射，每隔一天) 在 Cal27 来源的异种移植小鼠中显示出抗肿瘤作用。Animal Model:orthotopic mouse LUAD model
Dosage:75 mg/kg for Thymol, 10 mg/kg for anti‐PD‐1 antibody
Administration:anti‐PD‐1 antibody: i.p., every 1 week from day 5 after tumor injection.Thymol: i.p., every 2 days from day 5 after tumor injection.
Result:Inhibited the progression of LUAD, and increased the survival of mice.Decreases IL4I1 level in tumors.Improved the efficacy of anti‐PD‐1 antibody.
体外研究：
Thymol (20 μM，24-48 小时) 可抑制 A549 细胞中的 IL4I1 表达 (24 小时) 并抑制芳烃受体 (AHR) 信号传导 (48 小时)。Thymol (5 μM，48 小时) 抑制 A549 细胞的上皮间质转化和运动活性。Thymol (0-600 μM，48 小时) 可抑制多种癌细胞类型 (Cal27、SCC4、SCC9、HeLa、H460、MDA-231 和 PC3 细胞) 的细胞增殖。Thymol (200 μg/mL) 诱导 A. flavus 中半胱天冬酶依赖性的分生孢子凋亡。
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