产品
编 号：F507088
分子式：C16H13Cl2NO4
分子量：354.18
分子式：C16H13Cl2NO4
分子量：354.18
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
320
In-stock
1g
400
In-stock
5g
784
In-stock
结构图
CAS No: 89796-99-6
产品详情
生物活性：
Aceclofenac is an orally active nonsteroidal anti-inflammatory agent (NSAID), with analgesic and anti-inflammatory properties. Aceclofenac is used for the research of osteoarthritis, ankylosing spondylitis, rheumatoid arthritis.
体内研究：
Aceclofenac exhibits Cmax (4.59 μg/mL) following oral administration (rat 20 mg/kg).Aceclofenac exhibits terminal elimination half-life (rat 3.24 h) due to high plasma clearance (rat 1.10 L/h/kg) following intravenous injection (rat 10 mg/kg).Animal Model:Male Sprague-Dawley rats weighing 32-340 g
Dosage:10 mg/kg for i.v., 20 mg/kg for p.o. (Pharmacokinetic Analysis)
Administration:Oral administration and intravenous injection
Result:T1/2 (3.24 h), Cmax (4.59 μg/mL for p.o.).
体外研究：
Aceclofenac (1-30 μM; 72 hours) significantly decreases interleukin-6 production and fully blocks prostaglandin E2 synthesis by IL-1β- or LPS-stimulated human chondrocytes.Aceclofenac inhibits COX-1 with IC50 values superior to 100 μM, but decreases by 50% COX-2 activity at the concentration of 0.77 μM in the whole blood test.Aceclofenac increases the synthesis of interleukin 1 receptor antagonist and decreases the production of nitric oxide in human articular chondrocytes.
Aceclofenac is an orally active nonsteroidal anti-inflammatory agent (NSAID), with analgesic and anti-inflammatory properties. Aceclofenac is used for the research of osteoarthritis, ankylosing spondylitis, rheumatoid arthritis.
体内研究：
Aceclofenac exhibits Cmax (4.59 μg/mL) following oral administration (rat 20 mg/kg).Aceclofenac exhibits terminal elimination half-life (rat 3.24 h) due to high plasma clearance (rat 1.10 L/h/kg) following intravenous injection (rat 10 mg/kg).Animal Model:Male Sprague-Dawley rats weighing 32-340 g
Dosage:10 mg/kg for i.v., 20 mg/kg for p.o. (Pharmacokinetic Analysis)
Administration:Oral administration and intravenous injection
Result:T1/2 (3.24 h), Cmax (4.59 μg/mL for p.o.).
体外研究：
Aceclofenac (1-30 μM; 72 hours) significantly decreases interleukin-6 production and fully blocks prostaglandin E2 synthesis by IL-1β- or LPS-stimulated human chondrocytes.Aceclofenac inhibits COX-1 with IC50 values superior to 100 μM, but decreases by 50% COX-2 activity at the concentration of 0.77 μM in the whole blood test.Aceclofenac increases the synthesis of interleukin 1 receptor antagonist and decreases the production of nitric oxide in human articular chondrocytes.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备