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编 号:F507004
分子式:C10H12N4O5S
分子量:300.29
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10mM*1mL in DMSO
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1g
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5g
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生物活性:
Tazobactam (CL-298741) is a potent β-lactamases inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research.

体内研究:
Tazobactam (CL-298741) (1000 mg/kg; i.p.; four times a day, for 36 and 84 hours; BALB/c mice) decreases the number of bacteria in mice and survived in low doses.Animal Model:BALB/c mice
Dosage:1000 mg/kg
Administration:Intraperitoneal injection; four times a day, for 36 and 84 hours
Result:Decraesed the number of bacteria and neutrophils in BALF than in the control group.

体外研究:
Tazobactam (CL-298741) (5 μg/mL; 18 hours) has bactericidal activity and inhibit the growth of the bacteria in a dose-dependent manner.Tazobactam (CL-298741) (1-10 μg/mL; 6 hours; Prot. vulgaris and M. morgan) inhibitsvarious types β-lactamase activity and with ID50 values of < 10 μg/mL, respectively.
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