产品
编 号：F506551
分子式：C21H20N4O2
分子量：360.41
分子式：C21H20N4O2
分子量：360.41
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
100mg
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结构图
CAS No: 896705-16-1
产品详情
生物活性：
BMH-21 is a first-in-class DNA intercalator which inhibits RNA polymerase I (Pol I) transcription. BMH-21 possesses anticancer activity.
体内研究：
BMH-21 (50 mg/kg; i.p.; daily; for 6 days) inhibits HCT116 colon cancer tumor growth in vivo.Animal Model:6-week old athymic NCr nu/nu mice, with HCT116 colorectal carcinoma xenograft
Dosage:50 mg/kg
Administration:Intraperitoneal injection, daily, for 6 days
Result:Significantly inhibited HCT116 colon cancer tumor growth.
体外研究：
BMH-21 binds ribosomal DNA and inhibits Pol I transcription.?BMH-21 inhibits RNA polymerase I independent of DNA damage response.?BMH-21 intercalates into double strand (ds) DNA and has binding preference towards GC-rich DNA sequences.?BMH-21 (1 μM; 3 hours) acts in a DNA damage independent manner to activate nucleolar stress and RPA194 degradation.
BMH-21 is a first-in-class DNA intercalator which inhibits RNA polymerase I (Pol I) transcription. BMH-21 possesses anticancer activity.
体内研究：
BMH-21 (50 mg/kg; i.p.; daily; for 6 days) inhibits HCT116 colon cancer tumor growth in vivo.Animal Model:6-week old athymic NCr nu/nu mice, with HCT116 colorectal carcinoma xenograft
Dosage:50 mg/kg
Administration:Intraperitoneal injection, daily, for 6 days
Result:Significantly inhibited HCT116 colon cancer tumor growth.
体外研究：
BMH-21 binds ribosomal DNA and inhibits Pol I transcription.?BMH-21 inhibits RNA polymerase I independent of DNA damage response.?BMH-21 intercalates into double strand (ds) DNA and has binding preference towards GC-rich DNA sequences.?BMH-21 (1 μM; 3 hours) acts in a DNA damage independent manner to activate nucleolar stress and RPA194 degradation.
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