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编 号：F506536
分子式：C20H32O5
分子量：352.47
分子式：C20H32O5
分子量：352.47
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CAS No: 89663-86-5
产品详情
生物活性：
Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC50 value of 25.74 nM.
体外研究：
Lipoxin A4 (LXA4) inhibits the expression of IL-6 and IL-8 in NHEKs. Lipoxin A4 downregulates the expression of cyclin D1.Lipoxin A4 also suppresses the ERK1/2 phosphorylation and NF-kB-p65 nuclear translocation of NHEKs.LXA4 (100 nM; preincubation for 30 minutes)inhibits the proliferation of NHEKs with or without stimulating by LPS (10 μg/mL). LXA4 pretreatment (100? nM for 30?minutes) downregulates the LPS-induced secretion and expression of HMGB1 in keratinocytes.
Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC50 value of 25.74 nM.
体外研究：
Lipoxin A4 (LXA4) inhibits the expression of IL-6 and IL-8 in NHEKs. Lipoxin A4 downregulates the expression of cyclin D1.Lipoxin A4 also suppresses the ERK1/2 phosphorylation and NF-kB-p65 nuclear translocation of NHEKs.LXA4 (100 nM; preincubation for 30 minutes)inhibits the proliferation of NHEKs with or without stimulating by LPS (10 μg/mL). LXA4 pretreatment (100? nM for 30?minutes) downregulates the LPS-induced secretion and expression of HMGB1 in keratinocytes.
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