产品
编 号：F503984
分子式：C23H22N2O4S2
分子量：454.56
分子式：C23H22N2O4S2
分子量：454.56
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 890819-86-0
产品详情
生物活性：
ML349 is a potent and specific acyl protein thioesterase 2(APT2)/lysophospholipase 2 (LYPLA2) inhibitor with a Ki of 120 nM. ML349 is also an inhibitor of LYPLA2 with an IC50 of 144 nM.
体外研究：
ML349 is an inhibitor of acyl protein thioesterase 1 and 2 (APT-1 and APT-2) with Kisof>10000 and 120±20 nM, respectively. ML349 is also an inhibitor of both LYPLA1 and LYPLA2 with IC50s of >3000 and 144 nM, respectivley. ML348 and ML349 do not decrease cell viability, but they lead to a slight activation of AKT in NRAS mutant cells.
ML349 is a potent and specific acyl protein thioesterase 2(APT2)/lysophospholipase 2 (LYPLA2) inhibitor with a Ki of 120 nM. ML349 is also an inhibitor of LYPLA2 with an IC50 of 144 nM.
体外研究：
ML349 is an inhibitor of acyl protein thioesterase 1 and 2 (APT-1 and APT-2) with Kisof>10000 and 120±20 nM, respectively. ML349 is also an inhibitor of both LYPLA1 and LYPLA2 with IC50s of >3000 and 144 nM, respectivley. ML348 and ML349 do not decrease cell viability, but they lead to a slight activation of AKT in NRAS mutant cells.
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