产品
编 号：F502867
分子式：C6H10N2O3
分子量：158.16
分子式：C6H10N2O3
分子量：158.16
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规格
价格
是否有货
25mg
询价
询价
100mg
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询价
结构图
CAS No: 88929-35-5
产品详情
生物活性：
(S)-oxiracetam (S-ORC) is an inhibitor targeting apoptosis. S-ORC reduces brain infarct size and lessens neurological dysfunction in middle cerebral artery occlusion/reperfusion (MCAO/R) models. S-ORC prevents neuronal apoptosis via activating PI3K/Akt/GSK3β signaling pathway via α7 nAChR after ischemic stroke. S-ORC can prevent neuronal death after ischemic stroke.
体内研究：
(S)-Oxiracetam (0.12，0.24，0.48 g/kg；静脉注射，每天一次持续 7 天) 在雄性 Sprague-Dawley 大鼠诱导的 MACO/R 模型中，显著减少梗死面积，减轻行为功能障碍，抑制神经元凋亡并激活 PI3K/Akt/GSK3β 信号通路。Animal Model:scopolamine-induced amnesia models in Swiss albino mice.
Dosage:0.12, 0.24, 0.48 g/kg, once daily for 7 days
Administration:Intravenous injection (i.v.)
Result:Decreased the infarct size of rats to 26.04 ± 1.07%, 21.66 ± 2.27%, 12.26 ± 5.59% compared with the sham group at 0.12 g/kg, 0.24 g/kg, 0.48 g/kg, respectively.Increased neurological scores compared with the MCAO/R group.Protected neurons from apoptosis compared to sham group.Increased the α7 nAChR and the phosphorylation of PI3K, Akt and GSK3β expression compared with MCAO/R group.Increased of GSH-PX concentration (189.54 units, 193.07 units, and 203.98 untis, respectively).
体外研究：
(S)-Oxiracetam (1，10，100 μM；24 h) 保护胎鼠原代皮层神经元免受 OGD/R 损伤并激活 PI3K/Akt/GSK3β 信号通路依赖于 α7 nAChR。
(S)-oxiracetam (S-ORC) is an inhibitor targeting apoptosis. S-ORC reduces brain infarct size and lessens neurological dysfunction in middle cerebral artery occlusion/reperfusion (MCAO/R) models. S-ORC prevents neuronal apoptosis via activating PI3K/Akt/GSK3β signaling pathway via α7 nAChR after ischemic stroke. S-ORC can prevent neuronal death after ischemic stroke.
体内研究：
(S)-Oxiracetam (0.12，0.24，0.48 g/kg；静脉注射，每天一次持续 7 天) 在雄性 Sprague-Dawley 大鼠诱导的 MACO/R 模型中，显著减少梗死面积，减轻行为功能障碍，抑制神经元凋亡并激活 PI3K/Akt/GSK3β 信号通路。Animal Model:scopolamine-induced amnesia models in Swiss albino mice.
Dosage:0.12, 0.24, 0.48 g/kg, once daily for 7 days
Administration:Intravenous injection (i.v.)
Result:Decreased the infarct size of rats to 26.04 ± 1.07%, 21.66 ± 2.27%, 12.26 ± 5.59% compared with the sham group at 0.12 g/kg, 0.24 g/kg, 0.48 g/kg, respectively.Increased neurological scores compared with the MCAO/R group.Protected neurons from apoptosis compared to sham group.Increased the α7 nAChR and the phosphorylation of PI3K, Akt and GSK3β expression compared with MCAO/R group.Increased of GSH-PX concentration (189.54 units, 193.07 units, and 203.98 untis, respectively).
体外研究：
(S)-Oxiracetam (1，10，100 μM；24 h) 保护胎鼠原代皮层神经元免受 OGD/R 损伤并激活 PI3K/Akt/GSK3β 信号通路依赖于 α7 nAChR。
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