产品
编 号:F502497
分子式:C23H21ClO6
分子量:428.86
产品类型
结构图
CAS No: 888042-13-5
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产品详情
生物活性:
GF 15 is a potent inhibitor of centrosomal clustering in tumor cells.
体内研究:
Treatment of mouse xenograft models of human colon cancer and multiple myeloma with GF 15 results in tumor growth inhibition and significantly prolonged survival.
体外研究:
GF 15 leads to multipolar mitosis induction with an EC50 of 900 nM. GF 15 exhibits potent cytotoxicity in a concentration-dependent manner against a broad spectrum of tumor cell types including colon, cervix, glioblastoma, pancreas, leukemia, and myeloma-derived cell lines with IC50s of 1-5 μM.